PRPF31 and TMCC2

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		PRPF31	TMCC2
Description		pre-mRNA processing factor 31	transmembrane and coiled-coil domain family 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm U2-type Spliceosomal Complex U4 SnRNP U4atac SnRNP Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome MLL1 Complex Spliceosomal Tri-snRNP Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Integral Component Of Membrane
	Molecular Function	RNA Binding Protein Binding U4 SnRNA Binding U4atac SnRNA Binding Ribonucleoprotein Complex Binding SnRNP Binding	Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly MRNA Splicing, Via Spliceosome SnoRNA Localization Ribonucleoprotein Complex Localization	Amyloid Precursor Protein Metabolic Process
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases		Retinitis pigmentosa (RP)
GWAS		Change in HbA1c levels in response to metformin treatment in type 2 diabetes ( 29650774)	Blood protein levels ( 28240269) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular hemoglobin concentration ( 27863252) Mean corpuscular volume ( 27863252) Mean platelet volume ( 22139419 24026423 19820697 27863252) Platelet count ( 22139419) Platelet distribution width ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		76 interacting genes: C1QTNF1 CALCOCO2 CBY2 CCDC136 CCDC33 CCDC57 CCNDBP1 CDCA7L CEP70 DVL2 EFEMP2 FANCA FANCC FASTK GOLGA2 HNRNPH2 HNRNPK JAKMIP2 KCTD6 KHDRBS2 KHDRBS3 KRT15 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-8 KRTAP10-9 LDOC1 LURAP1 LZTS2 MDFI MEOX2 MID2 MIPOL1 MKRN3 MTUS2 NCAPH2 NDUFB9 NOTCH2NLA PAK5 PDE4DIP PHC2 PHF5A PNMA1 PNMA2 PPIH PRICKLE1 PRPF3 PSTPIP1 RACK1 RBM25 RBM4 RBMX RBMY1A1 RBMY1F RINT1 SIAH1 SNRNP200 SSX2IP STX11 TADA2A TFIP11 TLE5 TMCC2 TP53BP2 TRIM27 TRIM41 TSGA10 USP15 ZFP64 ZNF24 ZNF250 ZNF408 ZNF417 ZNF473 ZNF587	29 interacting genes: AKT1 AMOTL2 APP CCDC33 CDR2 CFAP206 DIP2A DPY30 EIF4E2 FAM161A FAM74A4 FAM90A1 FBF1 HGS HNRNPLL HSPD1 IQUB KAT5 PRPF31 PTOV1 RHOXF2 TLE5 UBA1 WT1-AS ZNF250 ZNF417 ZNF581 ZNF587 ZNF688
Entrez ID		26121	9911
HPRD ID		05917	11040
Ensembl ID		ENSG00000105618	ENSG00000133069
Uniprot IDs		Q8WWY3	A0A0C4DFR1 O75069 Q8IW47
PDB IDs		2OZB 3JCR 3SIU 3SIV 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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