TMCC2 and DPY30

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TMCC2	DPY30
Description		transmembrane and coiled-coil domain family 2	dpy-30 histone methyltransferase complex regulatory subunit
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Integral Component Of Membrane	Nucleus Nucleoplasm Golgi Apparatus Trans-Golgi Network Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Amyloid Precursor Protein Metabolic Process	Endosomal Transport Regulation Of Megakaryocyte Differentiation Histone H3-K4 Methylation
Pathways			PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular hemoglobin concentration ( 27863252) Mean corpuscular volume ( 27863252) Mean platelet volume ( 22139419 24026423 19820697 27863252) Platelet count ( 22139419) Platelet distribution width ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)
Interacting Genes		29 interacting genes: AKT1 AMOTL2 APP CCDC33 CDR2 CFAP206 DIP2A DPY30 EIF4E2 FAM161A FAM74A4 FAM90A1 FBF1 HGS HNRNPLL HSPD1 IQUB KAT5 PRPF31 PTOV1 RHOXF2 TLE5 UBA1 WT1-AS ZNF250 ZNF417 ZNF581 ZNF587 ZNF688	14 interacting genes: ARFGEF1 ASH2L CHMP2B DYDC1 GTF2I H3-4 KMT2C OTX1 PRPF3 PRRC2B PSMD14 SETD1A TMCC2 UBC
Entrez ID		9911	84661
HPRD ID		11040	17434
Ensembl ID		ENSG00000133069	ENSG00000162961
Uniprot IDs		A0A0C4DFR1 O75069 Q8IW47	B4DIS3 Q9C005
PDB IDs			3G36 4RIQ 4RT4 4RTA 6E2H
Enriched GO Terms of Interacting Partners?
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