PRPF31 and FANCA

Number of citations of the paper that reports this interaction (PubMedID 14499622)
12

Data Source:
BioGRID (two hybrid)

		PRPF31	FANCA
Description		pre-mRNA processing factor 31	FA complementation group A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm U2-type Spliceosomal Complex U4 SnRNP U4atac SnRNP Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome MLL1 Complex Spliceosomal Tri-snRNP Complex	Nucleus Nucleoplasm Cytoplasm Fanconi Anaemia Nuclear Complex
	Molecular Function	RNA Binding Protein Binding U4 SnRNA Binding U4atac SnRNA Binding Ribonucleoprotein Complex Binding SnRNP Binding	Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly MRNA Splicing, Via Spliceosome SnoRNA Localization Ribonucleoprotein Complex Localization	DNA Repair Male Meiotic Nuclear Division Male Gonad Development Female Gonad Development Interstrand Cross-link Repair Regulation Of Cell Proliferation Regulation Of Regulatory T Cell Differentiation Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Protein-containing Complex Assembly Regulation Of CD40 Signaling Pathway
Pathways		mRNA Splicing - Major Pathway	Fanconi Anemia Pathway
Drugs
Diseases		Retinitis pigmentosa (RP)	Fanconi anemia
GWAS		Change in HbA1c levels in response to metformin treatment in type 2 diabetes ( 29650774)	Hair morphology traits ( 30166351) Homocysteine levels ( 23824729) Intraocular pressure ( 29617998 29785010 31959993 30054594) Low tan response ( 29739929) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Skin pigmentation traits ( 30166351)
Interacting Genes		76 interacting genes: C1QTNF1 CALCOCO2 CBY2 CCDC136 CCDC33 CCDC57 CCNDBP1 CDCA7L CEP70 DVL2 EFEMP2 FANCA FANCC FASTK GOLGA2 HNRNPH2 HNRNPK JAKMIP2 KCTD6 KHDRBS2 KHDRBS3 KRT15 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-8 KRTAP10-9 LDOC1 LURAP1 LZTS2 MDFI MEOX2 MID2 MIPOL1 MKRN3 MTUS2 NCAPH2 NDUFB9 NOTCH2NLA PAK5 PDE4DIP PHC2 PHF5A PNMA1 PNMA2 PPIH PRICKLE1 PRPF3 PSTPIP1 RACK1 RBM25 RBM4 RBMX RBMY1A1 RBMY1F RINT1 SIAH1 SNRNP200 SSX2IP STX11 TADA2A TFIP11 TLE5 TMCC2 TP53BP2 TRIM27 TRIM41 TSGA10 USP15 ZFP64 ZNF24 ZNF250 ZNF408 ZNF417 ZNF473 ZNF587	48 interacting genes: AKT1 ALDOA ATP5F1B ATR AURKA AZIN1 BRCA1 CAPN1 CCT3 CD79A CDK1 CENPE DAXX DDX39B DNAJB1 DUS4L ENO1 FANCC FANCE FANCF FANCG GNB2 HES1 HPRT1 HSP90AA1 IFIT3 IKBKB KRT1 LIPG MKNK1 MX1 NAMPT NUB1 PRKAA1 PRPF31 PSMA5 RPL18 SGK1 SMARCA4 SMARCC1 SMARCD3 SNX5 SPTAN1 TAF10 TCERG1 TCP1 TPT1 ZNF24
Entrez ID		26121	2175
HPRD ID		05917	06186
Ensembl ID		ENSG00000105618	ENSG00000187741
Uniprot IDs		Q8WWY3	O15360
PDB IDs		2OZB 3JCR 3SIU 3SIV 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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