DOK2 and RASA1

Number of citations of the paper that reports this interaction (PubMedID 10508618)
26

Data Source:
HPRD (in vitro, in vivo)

		DOK2	RASA1
Description		docking protein 2	RAS p21 protein activator 1
Image
GO Annotations	Cellular Component	Cytosol	Ruffle Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding	Phosphotyrosine Residue Binding GTPase Activity GTPase Activator Activity Signaling Receptor Binding Protein Binding Potassium Channel Inhibitor Activity GTPase Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Axon Guidance Viral Process Leukocyte Migration	MAPK Cascade Mitotic Cytokinesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Ras Protein Signal Transduction Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of RNA Metabolic Process
Pathways		Tie2 Signaling RET signaling	Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases			RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
GWAS		Entorhinal cortical thickness ( 21116278) Mean corpuscular volume ( 20139978) Metabolite levels ( 23823483) Neuropathic pain in type 2 diabetes ( 24974787) Verbal declarative memory ( 25648963)	Chronotype ( 30696823) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Openness ( 21173776) Prostate cancer aggressiveness ( 25939597) Type 2 diabetes ( 30297969)
Interacting Genes		20 interacting genes: ABL1 APPL1 CRK CRKL CSK DOK3 EGFR HCK IL4R INPP5D KIFBP LCK LYN NCK1 POT1 RASA1 RET SRC STAT3 TEK	75 interacting genes: ABL1 AFAP1L2 ANXA6 APP ARHGAP1 ARHGAP5 AURKB BBS10 BCR BIRC5 CASP3 CASP7 CAV2 CD5 CSF1R CSK DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES FGFR1 G3BP1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 NCK1 NTRK1 OLIG1 PAG1 PDE6D PDGFRB PIK3R1 PTK2B PTPRC PXN RAB5A RACK1 RAP1A SERPINA4 SHC1 SLC9A2 SOCS3 SPSB1 SRC STAU1 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579
Entrez ID		9046	5921
HPRD ID		05411	00745
Ensembl ID		ENSG00000147443	ENSG00000145715
Uniprot IDs		B4DKQ6 O60496	P20936 Q59GK3
PDB IDs		2D9W 2DLW	1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS
Enriched GO Terms of Interacting Partners?
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