CIC and NFYC

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		CIC	NFYC
Description		capicua transcriptional repressor	nuclear transcription factor Y subunit gamma
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Protein-containing Complex Intracellular Membrane-bounded Organelle	Nuclear Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Brain Development Learning Memory Social Behavior Negative Regulation Of Transcription, DNA-templated Lung Alveolus Development	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Folding Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways			PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Bitter alcoholic beverage consumption ( 31046077)	Airway obstruction (FEV1/FVC<70%) in never smokers ( 30845926) Airway obstruction (FEV1/FVC<lower limit of normal) in never smokers ( 30845926) Depressive and manic episodes in bipolar disorder ( 26297903) Platelet count ( 21507922)
Interacting Genes		14 interacting genes: ATXN1 CENPJ CSNK2B GABPB1 GTPBP3 NFYC PICK1 PLD3 PLK1 PYCR2 SEC62 SETD2 TRIM22 ZNRD1	26 interacting genes: ADNP2 ARID2 ATF6 ATF6B BICRA BICRAL CIC CSN2 DST GAPDH LMO4 MYC NFYA NFYB POGZ SMAD2 SMAD3 SNX2 SP1 SREBF2 TAF11 TAF12 TAF6 TBP USF3 ZDHHC17
Entrez ID		23152	4802
HPRD ID		10831	05633
Ensembl ID		ENSG00000079432	ENSG00000066136
Uniprot IDs		A0A0A0MQR4 Q96RK0	Q13952
PDB IDs		2M41 4J2J 4J2L 6JRP	1N1J 4AWL 4CSR 6QMP 6QMQ 6QMS
Enriched GO Terms of Interacting Partners?
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