NFYC and ATF6B

Number of citations of the paper that reports this interaction (PubMedID 11158310)
90

Data Source:
HPRD (two hybrid, in vitro)

		NFYC	ATF6B
Description		nuclear transcription factor Y subunit gamma	activating transcription factor 6 beta
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Factor Complex	Nuclear Chromatin Nucleus Endoplasmic Reticulum Membrane Golgi Apparatus Integral Component Of Endoplasmic Reticulum Membrane Protein-DNA Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Transcription Regulatory Region DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Folding Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II	Transcription, DNA-templated Signal Transduction ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Airway obstruction (FEV1/FVC<70%) in never smokers ( 30845926) Airway obstruction (FEV1/FVC<lower limit of normal) in never smokers ( 30845926) Depressive and manic episodes in bipolar disorder ( 26297903) Platelet count ( 21507922)	Age-related macular degeneration ( 23577725) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Blood protein levels ( 30072576 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998) Mean corpuscular volume ( 27863252) Prostate cancer ( 23535732) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908)
Interacting Genes		26 interacting genes: ADNP2 ARID2 ATF6 ATF6B BICRA BICRAL CIC CSN2 DST GAPDH LMO4 MYC NFYA NFYB POGZ SMAD2 SMAD3 SNX2 SP1 SREBF2 TAF11 TAF12 TAF6 TBP USF3 ZDHHC17	9 interacting genes: ATF6 CDK6 CREBZF MBTPS1 MBTPS2 NFYA NFYC PHOX2A XBP1
Entrez ID		4802	1388
HPRD ID		05633	02992
Ensembl ID		ENSG00000066136	ENSG00000213676
Uniprot IDs		Q13952	A0A1U9X796 Q6AZW6 Q99941
PDB IDs		1N1J 4AWL 4CSR 6QMP 6QMQ 6QMS
Enriched GO Terms of Interacting Partners?
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