GGA2 and IGF2R

Number of citations of the paper that reports this interaction (PubMedID 11387475)
128

Data Source:
HPRD (in vitro)

		GGA2	IGF2R
Description		golgi associated, gamma adaptin ear containing, ARF binding protein 2	insulin like growth factor 2 receptor
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GO Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Endosome Membrane Clathrin-coated Vesicle Early Endosome Membrane	Nuclear Envelope Lumen Lysosomal Membrane Endosome Early Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Membrane Clathrin Coat Transport Vesicle Endocytic Vesicle Trans-Golgi Network Transport Vesicle Clathrin-coated Vesicle Membrane Secretory Granule Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding ADP-ribosylation Factor Binding	G-protein Alpha-subunit Binding Retinoic Acid Binding Insulin-like Growth Factor-activated Receptor Activity Protein Binding Insulin-like Growth Factor Binding Mannose Binding Enzyme Binding Insulin-like Growth Factor II Binding Signaling Receptor Activity Identical Protein Binding Phosphoprotein Binding
	Biological Process	Intracellular Protein Transport Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Cellular Protein Metabolic Process	Liver Development Receptor-mediated Endocytosis Lysosomal Transport Signal Transduction G Protein-coupled Receptor Signaling Pathway Spermatogenesis Post-embryonic Development Animal Organ Regeneration Response To Retinoic Acid Positive Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation By Host Of Viral Process Insulin-like Growth Factor Receptor Signaling Pathway Membrane Organization
Pathways		TBC/RABGAPs Amyloid fiber formation	Golgi Associated Vesicle Biogenesis Neutrophil degranulation Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Mecasermin alpha-D-mannose 6-phosphate Cerliponase alfa
Diseases			Hepatocellular carcinoma
GWAS			Blood protein levels ( 30072576 29875488 28240269) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain lesion load ( 19010793) Coronary artery disease ( 29212778) Lipoprotein (a) levels ( 26377243) Periodontitis (CDC/AAP) ( 24024966) Serum metabolite concentrations in chronic kidney disease ( 29545352)
Interacting Genes		34 interacting genes: ADRA2B AFTPH APP ARF1 ARF3 ATXN1 BACE1 BACE2 CA8 CCDC91 CLINT1 CLTC FBXO7 GGA1 GGA3 GOLGA2 HGS HTT IGF2R LRP3 M6PR MAP3K1 PIN1 RABEP1 RABGEF1 RNF11 SORL1 SORT1 SPG21 STAB1 SYNRG TOLLIP TRIM23 VPS18	14 interacting genes: AGA ATXN1 CREG1 CSNK2A1 CTSD GGA1 GGA2 GGA3 GZMB IGF2 PACS1 PLAU PLAUR PLIN3
Entrez ID		23062	3482
HPRD ID		09347	00928
Ensembl ID		ENSG00000103365	ENSG00000197081
Uniprot IDs		Q9UJY4	P11717
PDB IDs		1MHQ	1E6F 1GP0 1GP3 1GQB 1JPL 1JWG 1LF8 2CNJ 2L29 2L2A 2M68 2M6T 2V5N 2V5O 2V5P 5IEI 6N5X 6N5Y
Enriched GO Terms of Interacting Partners?
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