GGA2 and SORT1

Number of citations of the paper that reports this interaction (PubMedID 11331584)
123

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		GGA2	SORT1
Description		golgi associated, gamma adaptin ear containing, ARF binding protein 2	sortilin 1
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GO Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Endosome Membrane Clathrin-coated Vesicle Early Endosome Membrane	Lysosome Lysosomal Membrane Early Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Endosome Membrane Integral Component Of Membrane Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle Dendrite Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane Golgi Cisterna Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding ADP-ribosylation Factor Binding	Protein Binding Nerve Growth Factor Receptor Activity Enzyme Binding Neurotensin Receptor Activity, Non-G Protein-coupled Nerve Growth Factor Binding
	Biological Process	Intracellular Protein Transport Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Cellular Protein Metabolic Process	Ossification Protein Targeting To Lysosome Post-Golgi Vesicle-mediated Transport Golgi To Endosome Transport Endocytosis G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Multicellular Organism Development Endosome To Lysosome Transport Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Myotube Differentiation Vesicle Organization Endosome Transport Via Multivesicular Body Sorting Pathway Response To Insulin Nerve Growth Factor Signaling Pathway Negative Regulation Of Fat Cell Differentiation Glucose Import Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane To Endosome Transport Negative Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Epithelial Cell Apoptotic Process
Pathways		TBC/RABGAPs Amyloid fiber formation	Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS			Abdominal aortic aneurysm ( 27899403) Cholesterol, total ( 24097068 25961943 20686565) Chronic kidney disease ( 20383146) Cognitive ability ( 29186694) Coronary artery disease ( 21239051 24262325 26343387 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378988 21378990) HDL cholesterol ( 25961943) LDL cholesterol ( 24097068 18193043 18193044 19060906 19060910 21347282 25961943 20686565) LDL cholesterol levels ( 28334899) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Low density lipoprotein cholesterol levels ( 30718733) Metabolite levels ( 21909109) Metabolite levels (lipoprotein measures) ( 27005778) Myocardial infarction ( 26343387) Myocardial infarction (early onset) ( 19198609) Peripheral artery disease ( 31285632) Progranulin levels ( 21087763 29186428) Ratio of apolipoprotein A1 to apolipoprotein B ( 29084231) Response to statin therapy ( 20339536) Total cholesterol levels ( 28334899)
Interacting Genes		34 interacting genes: ADRA2B AFTPH APP ARF1 ARF3 ATXN1 BACE1 BACE2 CA8 CCDC91 CLINT1 CLTC FBXO7 GGA1 GGA3 GOLGA2 HGS HTT IGF2R LRP3 M6PR MAP3K1 PIN1 RABEP1 RABGEF1 RNF11 SORL1 SORT1 SPG21 STAB1 SYNRG TOLLIP TRIM23 VPS18	9 interacting genes: BDNF GGA1 GGA2 LRPAP1 NGF NGFR NTS SORCS1 SORL1
Entrez ID		23062	6272
HPRD ID		09347	03910
Ensembl ID		ENSG00000103365	ENSG00000134243
Uniprot IDs		Q9UJY4	Q99523
PDB IDs		1MHQ	3F6K 3G2U 3G2V 4MSL 4N7E 4PO7 5MRH 5MRI 6EHO
Enriched GO Terms of Interacting Partners?
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