ZHX3 and NFYA

Number of citations of the paper that reports this interaction (PubMedID 12659632)
16

Data Source:
HPRD (two hybrid)

		ZHX3	NFYA
Description		zinc fingers and homeoboxes 3	nuclear transcription factor Y subunit alpha
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Nuclear Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated	Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Rhythmic Process
Pathways			PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Fasting blood glucose adjusted for BMI ( 25625282) Heel bone mineral density ( 30598549) Height ( 31562340) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 29403010) Male-pattern baldness ( 28196072) Multiple sclerosis ( 31604244 24076602) Non-response to bupropion and depression ( 27622933) Resting heart rate ( 27798624) Total cholesterol levels ( 29403010) Type 2 diabetes ( 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)	White blood cell count ( 27863252)
Interacting Genes		6 interacting genes: ATXN1 NFYA NLK SH2D2A ZHX1 ZHX2	42 interacting genes: APP APPBP2 ATF6 ATF6B BRCA1 CCNA2 CDC25A CDK2 CDKN1A CEBPA CSNK2A1 E2F6 ELF1 GTF2A1 HMGA1 JUN KPNB1 LUC7L2 NEU1 NFYB NFYC NR5A1 PAPOLG POGZ POU2F1 PWP1 SP1 SPI1 SREBF2 SRF SRSF1 TAF11 TAF12 TAF6 TCAF1 TP53 USF1 USF2 ZC3H10 ZHX1 ZHX2 ZHX3
Entrez ID		23051	4800
HPRD ID		10320	01793
Ensembl ID		ENSG00000174306	ENSG00000001167
Uniprot IDs		Q9H4I2	A0A024RD22 P23511
PDB IDs		2DA5 2DN0	4AWL 6QMP
Enriched GO Terms of Interacting Partners?
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