ZHX3 and NLK

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		ZHX3	NLK
Description		zinc fingers and homeoboxes 3	nemo like kinase
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding SH2 Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated	MAPK Cascade Regulation Of Transcription, DNA-templated Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Regulation Of Gene Expression Peptidyl-threonine Phosphorylation Negative Regulation Of Wnt Signaling Pathway Intracellular Signal Transduction Serine Phosphorylation Of STAT Protein Protein Autophosphorylation Protein Stabilization
Pathways			Ca2+ pathway
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Fasting blood glucose adjusted for BMI ( 25625282) Heel bone mineral density ( 30598549) Height ( 31562340) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 29403010) Male-pattern baldness ( 28196072) Multiple sclerosis ( 31604244 24076602) Non-response to bupropion and depression ( 27622933) Resting heart rate ( 27798624) Total cholesterol levels ( 29403010) Type 2 diabetes ( 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)	Non-response to bupropion and depression ( 27622933)
Interacting Genes		6 interacting genes: ATXN1 NFYA NLK SH2D2A ZHX1 ZHX2	23 interacting genes: ASGR1 ATXN1 CREBBP CUL1 FBXW5 FOXO4 FOXP3 GRN HIPK2 KRTAP10-3 KRTAP4-2 KRTAP5-6 KRTAP5-9 LEF1 MYB MYBL1 QRICH1 RCHY1 SDR16C5 SKP2 STAT3 USP4 ZHX3
Entrez ID		23051	51701
HPRD ID		10320	17637
Ensembl ID		ENSG00000174306	ENSG00000087095
Uniprot IDs		Q9H4I2	A0A024QZ12 Q9UBE8
PDB IDs		2DA5 2DN0
Enriched GO Terms of Interacting Partners?
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