FBLN1 and CCN2

Number of citations of the paper that reports this interaction (PubMedID 9927660)
48

Data Source:
BioGRID (pull down)

		FBLN1	CCN2
Description		fibulin 1	cellular communication network factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber	Extracellular Region Extracellular Space Cis-Golgi Network Cytosol Plasma Membrane Cell Cortex Extracellular Matrix Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix
	Molecular Function	Fibronectin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein C-terminus Binding Peptidase Activator Activity Identical Protein Binding Protein-containing Complex Binding Fibrinogen Binding	Fibronectin Binding Integrin Binding Protein Binding Insulin-like Growth Factor Binding Protein C-terminus Binding Growth Factor Activity Heparin Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Embryo Implantation Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization Negative Regulation Of ERK1 And ERK2 Cascade Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Cell Motility Negative Regulation Of Stem Cell Proliferation	Cartilage Condensation Ossification Angiogenesis Tissue Homeostasis Transcription Initiation From RNA Polymerase II Promoter Cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Aging Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Response To Glucose Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration Cell Differentiation Lung Development Regulation Of Chondrocyte Differentiation Response To Estradiol Positive Regulation Of Collagen Biosynthetic Process Response To Anoxia Intracellular Signal Transduction Chondrocyte Proliferation Response To Amino Acid Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Peptide Hormone Positive Regulation Of Cell Differentiation Positive Regulation Of JNK Cascade Positive Regulation Of Cell Activation Response To Mineralocorticoid Positive Regulation Of Stress Fiber Assembly Cytosolic Calcium Ion Transport Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cell Death Extracellular Matrix Constituent Secretion Positive Regulation Of G0 To G1 Transition Positive Regulation Of ERK1 And ERK2 Cascade Response To Fatty Acid DNA Biosynthetic Process Reactive Oxygen Species Metabolic Process
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription
Drugs
Diseases		Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses
GWAS		Blood protein levels ( 30072576) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Paneth cell defects in Crohn's disease ( 28352666) QT interval ( 29213071) Red blood cell count ( 27863252) Temperament (bipolar disorder) ( 22365631)
Interacting Genes		39 interacting genes: ACAN ADAMTSL2 ADAMTSL4 APOA1 APP ATN1 BHLHE40 CACNA1A CCN2 CCN3 DDIAS ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HSPG2 ITGB1 LTBP4 MCPH1 MFAP5 MOB4 NEDD1 NID1 NLGN3 NOTCH3 PLSCR1 SKIL SMAD3 SMAD4 TAF9 TANK TCF7L2 TDGF1 TLE5 VCAN YWHAQ	12 interacting genes: ACTB AP3D1 CCN3 ERBB4 FBLN1 HSPG2 LRP1 MTDH TGFB1 TGFB2 TGFB3 VEGFA
Entrez ID		2192	1490
HPRD ID		00629	00412
Ensembl ID		ENSG00000077942	ENSG00000118523
Uniprot IDs		P23142 Q8NBH6	P29279 Q5M8T4
PDB IDs
Enriched GO Terms of Interacting Partners?
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