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CCN2 and HSPG2
Number of citations of the paper that reports this interaction (PubMedID
12811819
)
36
Data Source:
HPRD
(in vivo)
CCN2
HSPG2
Description
cellular communication network factor 2
heparan sulfate proteoglycan 2
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cis-Golgi Network
Cytosol
Plasma Membrane
Cell Cortex
Extracellular Matrix
Perinuclear Region Of Cytoplasm
Collagen-containing Extracellular Matrix
Extracellular Region
Basement Membrane
Extracellular Space
Golgi Lumen
Plasma Membrane
Focal Adhesion
Lysosomal Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Plasma Membrane Protein Complex
Molecular Function
Fibronectin Binding
Integrin Binding
Protein Binding
Insulin-like Growth Factor Binding
Protein C-terminus Binding
Growth Factor Activity
Heparin Binding
Amyloid-beta Binding
Calcium Ion Binding
Protein Binding
Protein C-terminus Binding
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Low-density Lipoprotein Particle Receptor Binding
Biological Process
Cartilage Condensation
Ossification
Angiogenesis
Tissue Homeostasis
Transcription Initiation From RNA Polymerase II Promoter
Cell Adhesion
Cell-matrix Adhesion
Signal Transduction
Integrin-mediated Signaling Pathway
Aging
Positive Regulation Of Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Epidermis Development
Response To Wounding
Response To Glucose
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Cell Migration
Cell Differentiation
Lung Development
Regulation Of Chondrocyte Differentiation
Response To Estradiol
Positive Regulation Of Collagen Biosynthetic Process
Response To Anoxia
Intracellular Signal Transduction
Chondrocyte Proliferation
Response To Amino Acid
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Response To Peptide Hormone
Positive Regulation Of Cell Differentiation
Positive Regulation Of JNK Cascade
Positive Regulation Of Cell Activation
Response To Mineralocorticoid
Positive Regulation Of Stress Fiber Assembly
Cytosolic Calcium Ion Transport
Positive Regulation Of Cardiac Muscle Contraction
Negative Regulation Of Cell Death
Extracellular Matrix Constituent Secretion
Positive Regulation Of G0 To G1 Transition
Positive Regulation Of ERK1 And ERK2 Cascade
Response To Fatty Acid
DNA Biosynthetic Process
Reactive Oxygen Species Metabolic Process
Retinoid Metabolic Process
Angiogenesis
Glycosaminoglycan Biosynthetic Process
Glycosaminoglycan Catabolic Process
Lipid Metabolic Process
Receptor-mediated Endocytosis
Inflammatory Response
Brain Development
Animal Organ Morphogenesis
Tissue Development
Negative Regulation Of Angiogenesis
Cell Differentiation
Extracellular Matrix Organization
Cellular Protein Metabolic Process
Cardiovascular System Development
Pathways
YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX3 regulates YAP1-mediated transcription
Degradation of the extracellular matrix
Degradation of the extracellular matrix
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG biosynthesis
HS-GAG degradation
Integrin cell surface interactions
Laminin interactions
Laminin interactions
Non-integrin membrane-ECM interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective EXT2 causes exostoses 2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Retinoid metabolism and transport
Amyloid fiber formation
Drugs
Palifermin
Diseases
Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS
Atrial fibrillation (
30061737
)
Height (
28552196
)
Interacting Genes
12 interacting genes:
ACTB
AP3D1
CCN3
ERBB4
FBLN1
HSPG2
LRP1
MTDH
TGFB1
TGFB2
TGFB3
VEGFA
31 interacting genes:
APP
ATF7IP
ATN1
BMP1
CACNA1A
CCN2
COL13A1
ECM1
FBLN1
FBLN2
FBN1
FGF2
FGF7
FGFBP1
FN1
GFI1B
GRN
ITGA2
ITGB1
LAMA1
MTDH
NID1
NID2
PDGFA
PDGFB
PRELP
PRPF40A
SPARC
TTR
UBC
VWA1
Entrez ID
1490
3339
HPRD ID
00412
00804
Ensembl ID
ENSG00000118523
ENSG00000142798
Uniprot IDs
P29279
Q5M8T4
P98160
PDB IDs
3SH4
3SH5
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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