FBLN1 and ADAMTSL2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		FBLN1	ADAMTSL2
Description		fibulin 1	ADAMTS like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber	Extracellular Matrix
	Molecular Function	Fibronectin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein C-terminus Binding Peptidase Activator Activity Identical Protein Binding Protein-containing Complex Binding Fibrinogen Binding	Protein Binding Peptidase Activity Microfibril Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Embryo Implantation Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization Negative Regulation Of ERK1 And ERK2 Cascade Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Cell Motility Negative Regulation Of Stem Cell Proliferation	Proteolysis Extracellular Matrix Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Lobar Bronchus Epithelium Development
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases		Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses	Geleophysic dysplasia
GWAS		Blood protein levels ( 30072576) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Paneth cell defects in Crohn's disease ( 28352666) QT interval ( 29213071) Red blood cell count ( 27863252) Temperament (bipolar disorder) ( 22365631)
Interacting Genes		39 interacting genes: ACAN ADAMTSL2 ADAMTSL4 APOA1 APP ATN1 BHLHE40 CACNA1A CCN2 CCN3 DDIAS ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HSPG2 ITGB1 LTBP4 MCPH1 MFAP5 MOB4 NEDD1 NID1 NLGN3 NOTCH3 PLSCR1 SKIL SMAD3 SMAD4 TAF9 TANK TCF7L2 TDGF1 TLE5 VCAN YWHAQ	1 interacting genes: FBLN1
Entrez ID		2192	9719
HPRD ID		00629	11096
Ensembl ID		ENSG00000077942	ENSG00000197859
Uniprot IDs		P23142 Q8NBH6	B1B0D4 Q86TH1
PDB IDs
Enriched GO Terms of Interacting Partners?
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