CCN2 and TGFB3

Number of citations of the paper that reports this interaction (PubMedID 10457363)
137

Data Source:
HPRD (in vivo)

		CCN2	TGFB3
Description		cellular communication network factor 2	transforming growth factor beta 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cis-Golgi Network Cytosol Plasma Membrane Cell Cortex Extracellular Matrix Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Nucleus Plasma Membrane Cell Surface T-tubule Platelet Alpha Granule Lumen Neuronal Cell Body Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix
	Molecular Function	Fibronectin Binding Integrin Binding Protein Binding Insulin-like Growth Factor Binding Protein C-terminus Binding Growth Factor Activity Heparin Binding	Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Protein-containing Complex Binding Transforming Growth Factor Beta Binding
	Biological Process	Cartilage Condensation Ossification Angiogenesis Tissue Homeostasis Transcription Initiation From RNA Polymerase II Promoter Cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Aging Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Response To Glucose Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration Cell Differentiation Lung Development Regulation Of Chondrocyte Differentiation Response To Estradiol Positive Regulation Of Collagen Biosynthetic Process Response To Anoxia Intracellular Signal Transduction Chondrocyte Proliferation Response To Amino Acid Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Peptide Hormone Positive Regulation Of Cell Differentiation Positive Regulation Of JNK Cascade Positive Regulation Of Cell Activation Response To Mineralocorticoid Positive Regulation Of Stress Fiber Assembly Cytosolic Calcium Ion Transport Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cell Death Extracellular Matrix Constituent Secretion Positive Regulation Of G0 To G1 Transition Positive Regulation Of ERK1 And ERK2 Cascade Response To Fatty Acid DNA Biosynthetic Process Reactive Oxygen Species Metabolic Process	Activation Of MAPK Activity Response To Hypoxia In Utero Embryonic Development Platelet Degranulation Transforming Growth Factor Beta Receptor Signaling Pathway Salivary Gland Morphogenesis Female Pregnancy Aging Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Positive Regulation Of Bone Mineralization BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mammary Gland Development Response To Progesterone Positive Regulation Of Collagen Biosynthetic Process Response To Laminar Fluid Shear Stress Wound Healing Regulation Of Cell Proliferation Odontogenesis Uterine Wall Breakdown Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Ossification Involved In Bone Remodeling Cell-cell Junction Organization Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Digestive Tract Development Embryonic Neurocranium Morphogenesis Inner Ear Development Positive Regulation Of Protein Secretion Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cell Division Face Morphogenesis Frontal Suture Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Secondary Palate Development Detection Of Hypoxia Negative Regulation Of Vascular Smooth Muscle Cell Proliferation Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription	Platelet degranulation Molecules associated with elastic fibres ECM proteoglycans
Drugs			1,4-Diethylene Dioxide
Diseases			Arrhythmogenic right ventricular cardiomyopathy (ARVC) Graft-versus-host disease Ossification of the posterior longitudinal ligament of spine (OPLL) Allograft rejection Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS
Interacting Genes		12 interacting genes: ACTB AP3D1 CCN3 ERBB4 FBLN1 HSPG2 LRP1 MTDH TGFB1 TGFB2 TGFB3 VEGFA	13 interacting genes: ACVRL1 CCL20 CCN2 CHMP2A ENG FMOD LTBP3 SDC4 TGFB2 TGFBR1 TGFBR2 TGFBR3 VASN
Entrez ID		1490	7043
HPRD ID		00412	01829
Ensembl ID		ENSG00000118523	ENSG00000119699
Uniprot IDs		P29279 Q5M8T4	A5YM40 B3KVH9 P10600
PDB IDs			1KTZ 1TGJ 1TGK 2PJY 3EO1 4UM9
Enriched GO Terms of Interacting Partners?
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