F8 and GGA1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		F8	GGA1
Description		coagulation factor VIII	golgi associated, gamma adaptin ear containing, ARF binding protein 1
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Nucleoplasm Early Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Early Endosome Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Copper Ion Binding Protein Binding Oxidoreductase Activity	Molecular_function Protein Binding ADP-ribosylation Factor Binding
	Biological Process	Platelet Degranulation ER To Golgi Vesicle-mediated Transport Acute-phase Response Blood Coagulation Blood Coagulation, Intrinsic Pathway Platelet Activation COPII Vesicle Coating Oxidation-reduction Process	Intracellular Protein Transport Protein Localization Protein Localization To Cell Surface Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport Cellular Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Toxin Transport Protein Localization To Ciliary Membrane
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation COPII-mediated vesicle transport Cargo concentration in the ER	TBC/RABGAPs Amyloid fiber formation
Drugs		Drotrecogin alfa Coagulation Factor IX (Recombinant) Anti-inhibitor coagulant complex Coagulation Factor IX Human
Diseases		Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Factor VIII levels ( 30586737) Red blood cell traits ( 23446634) Thrombosis ( 26908601) Venous thromboembolism ( 31420334)	Health literacy ( 31250787)
Interacting Genes		17 interacting genes: ASGR2 CALR CANX F10 F2 F9 GGA1 HSPA5 LMAN1 LRP1 MCFD2 PHYH PROC PROS1 TSC22D2 UBQLN1 VWF	38 interacting genes: ADRA2B AFTPH AP1AR APP ARF1 ARF3 ARF5 BACE1 BACE2 C1orf216 CCDC91 CDKL3 CDKN2A CLINT1 CLTC CSNK2A1 DTNB EGFR F8 GGA2 GGA3 IGF2R LRP3 M6PR RABEP1 RABGEF1 RNF11 RPS27A SCARB1 SMAD3 SORL1 SORT1 STAB1 SYNRG TOLLIP TSG101 UBC VPS18
Entrez ID		2157	26088
HPRD ID		02384	12078
Ensembl ID		ENSG00000185010	ENSG00000100083
Uniprot IDs		P00451	Q9UJY5
PDB IDs		1CFG 1D7P 1FAC 1IQD 2R7E 3CDZ 3HNB 3HNY 3HOB 3J2Q 3J2S 4BDV 4KI5 4PT6 4XZU 5K8D 6MF2	1J2J 1JWF 1JWG 1NA8 1NAF 1NWM 1O3X 1OM9 1OXZ 1PY1 1UJJ 1UJK 1X79 2DWX 2DWY 3G2S 3G2T 3G2U 3G2V 3G2W
Enriched GO Terms of Interacting Partners?
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