F8 and MCFD2

Number of citations of the paper that reports this interaction (PubMedID 15886209)
43

Data Source:
HPRD (in vitro)

		F8	MCFD2
Description		coagulation factor VIII	multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Golgi Membrane Endoplasmic Reticulum Membrane ER To Golgi Transport Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Copper Ion Binding Protein Binding Oxidoreductase Activity	Calcium Ion Binding Protein Binding
	Biological Process	Platelet Degranulation ER To Golgi Vesicle-mediated Transport Acute-phase Response Blood Coagulation Blood Coagulation, Intrinsic Pathway Platelet Activation COPII Vesicle Coating Oxidation-reduction Process	ER To Golgi Vesicle-mediated Transport Protein Transport Protein N-linked Glycosylation Via Asparagine COPII Vesicle Coating
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation COPII-mediated vesicle transport Cargo concentration in the ER	COPII-mediated vesicle transport Cargo concentration in the ER Transport to the Golgi and subsequent modification
Drugs		Drotrecogin alfa Coagulation Factor IX (Recombinant) Anti-inhibitor coagulant complex Coagulation Factor IX Human	Antihemophilic factor, human recombinant
Diseases		Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)	Combined deficiency of factors V and VIII (F5F8D)
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Factor VIII levels ( 30586737) Red blood cell traits ( 23446634) Thrombosis ( 26908601) Venous thromboembolism ( 31420334)	Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Response to statin therapy ( 20339536)
Interacting Genes		17 interacting genes: ASGR2 CALR CANX F10 F2 F9 GGA1 HSPA5 LMAN1 LRP1 MCFD2 PHYH PROC PROS1 TSC22D2 UBQLN1 VWF	3 interacting genes: APP F8 LMAN1
Entrez ID		2157	90411
HPRD ID		02384	09693
Ensembl ID		ENSG00000185010	ENSG00000180398
Uniprot IDs		P00451	B4DF17 Q8NI22
PDB IDs		1CFG 1D7P 1FAC 1IQD 2R7E 3CDZ 3HNB 3HNY 3HOB 3J2Q 3J2S 4BDV 4KI5 4PT6 4XZU 5K8D 6MF2	2VRG 3A4U 3LCP 3WHT 3WHU 3WNX 4YGB 4YGC 4YGD 4YGE
Enriched GO Terms of Interacting Partners?
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