F8 and LMAN1

Number of citations of the paper that reports this interaction (PubMedID 14629470)
9

Data Source:
HPRD (in vivo)

		F8	LMAN1
Description		coagulation factor VIII	lectin, mannose binding 1
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Golgi Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane Sarcomere COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Host Cell Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Copper Ion Binding Protein Binding Oxidoreductase Activity	Protein Binding Mannose Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Platelet Degranulation ER To Golgi Vesicle-mediated Transport Acute-phase Response Blood Coagulation Blood Coagulation, Intrinsic Pathway Platelet Activation COPII Vesicle Coating Oxidation-reduction Process	Protein Folding ER To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Golgi Organization Blood Coagulation Positive Regulation Of Organelle Organization Protein N-linked Glycosylation Via Asparagine Protein Exit From Endoplasmic Reticulum Early Endosome To Golgi Transport COPII Vesicle Coating Negative Regulation Of Protein Targeting To Mitochondrion
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation COPII-mediated vesicle transport Cargo concentration in the ER	COPII-mediated vesicle transport Cargo concentration in the ER Transport to the Golgi and subsequent modification
Drugs		Drotrecogin alfa Coagulation Factor IX (Recombinant) Anti-inhibitor coagulant complex Coagulation Factor IX Human	Antihemophilic factor, human recombinant
Diseases		Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)	Combined deficiency of factors V and VIII (F5F8D)
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Factor VIII levels ( 30586737) Red blood cell traits ( 23446634) Thrombosis ( 26908601) Venous thromboembolism ( 31420334)	Cardiac troponin-I levels ( 31014085) Chronotype ( 27494321) Morning vs. evening chronotype ( 27494321)
Interacting Genes		17 interacting genes: ASGR2 CALR CANX F10 F2 F9 GGA1 HSPA5 LMAN1 LRP1 MCFD2 PHYH PROC PROS1 TSC22D2 UBQLN1 VWF	4 interacting genes: APP BCAP31 F8 MCFD2
Entrez ID		2157	3998
HPRD ID		02384	03338
Ensembl ID		ENSG00000185010	ENSG00000074695
Uniprot IDs		P00451	A0A024R2A7 P49257
PDB IDs		1CFG 1D7P 1FAC 1IQD 2R7E 3CDZ 3HNB 3HNY 3HOB 3J2Q 3J2S 4BDV 4KI5 4PT6 4XZU 5K8D 6MF2	3A4U 3LCP 3WHT 3WHU 3WNX 4GKX 4GKY 4YGB 4YGC 4YGD 4YGE
Enriched GO Terms of Interacting Partners?
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