DOCK2 and ELMO1

Number of citations of the paper that reports this interaction (PubMedID 21930703)
15

Data Source:
BioGRID (two hybrid)

		DOCK2	ELMO1
Description		dedicator of cytokinesis 2	engulfment and cell motility 1
Image
GO Annotations	Cellular Component	Extracellular Region Cytosol Cytoskeleton Membrane Specific Granule Lumen Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Membrane Guanyl-nucleotide Exchange Factor Complex
	Molecular Function	GTPase Activator Activity Protein Binding Rac Guanyl-nucleotide Exchange Factor Activity T Cell Receptor Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	Membrane Raft Polarization Establishment Of T Cell Polarity Immunological Synapse Formation Myeloid Dendritic Cell Activation Involved In Immune Response Chemotaxis Small GTPase Mediated Signal Transduction Actin Cytoskeleton Organization Neutrophil Degranulation Positive Regulation Of GTPase Activity Macropinocytosis Positive Thymic T Cell Selection Negative Thymic T Cell Selection Alpha-beta T Cell Proliferation Regulation Of Defense Response To Virus By Virus Positive Regulation Of Phagocytosis	Phagocytosis, Engulfment Apoptotic Process Cell Migration Rac Protein Signal Transduction Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Regulation Of Defense Response To Virus By Virus
Pathways		Nef and signal transduction Neutrophil degranulation Factors involved in megakaryocyte development and platelet production	Nef and signal transduction Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Placental abruption ( 29884306) Pneumococcal bacteremia ( 27236921) Prostate cancer ( 29892016) Protein quantitative trait loci ( 18464913)	Alzheimer's disease (cognitive decline) ( 23535033) Anticoagulant levels ( 22216198) Body fat mass ( 28552196) Breast size ( 22747683) Celiac disease ( 22057235 20190752 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Cerebrospinal fluid AB1-42 levels ( 28247064) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Height ( 31562340) Inflammatory skin disease ( 25574825) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Mean platelet volume ( 27863252) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Platelet distribution width ( 27863252) Primary biliary cirrhosis ( 22961000) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) QT interval ( 20031603) Response to treatment for acute lymphoblastic leukemia ( 19176441) Rheumatoid arthritis ( 23143596) Sum eosinophil basophil counts ( 27863252) Trunk fat mass ( 28552196) Type 2 diabetes nephropathy ( 17653210)
Interacting Genes		27 interacting genes: CALCOCO2 CCNDBP1 CD247 CRKL ELMO1 HNRNPK KHDRBS1 KHDRBS2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 MDFI MTDH MTUS2 NOTCH2NLA PAK2 PLSCR1 RAC1 RAC2 TRIM23 VAV1	11 interacting genes: ADGRB1 ADGRB3 APBB1 DOCK1 DOCK2 DOCK5 FGD1 HCK RHOG TRIM54 ZNF398
Entrez ID		1794	9844
HPRD ID		09121	12102
Ensembl ID		ENSG00000134516	ENSG00000155849
Uniprot IDs		Q5XG91 Q92608	A4D1X5 Q92556
PDB IDs		2RQR 2YIN 3A98 3B13	2RQR 2VSZ 3A98
Enriched GO Terms of Interacting Partners?
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