DOCK2

Description		dedicator of cytokinesis 2
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GO Annotations	Cellular Component	Extracellular Region Cytosol Cytoskeleton Membrane Specific Granule Lumen Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding Rac Guanyl-nucleotide Exchange Factor Activity T Cell Receptor Binding
	Biological Process	Membrane Raft Polarization Establishment Of T Cell Polarity Immunological Synapse Formation Myeloid Dendritic Cell Activation Involved In Immune Response Chemotaxis Small GTPase Mediated Signal Transduction Actin Cytoskeleton Organization Neutrophil Degranulation Positive Regulation Of GTPase Activity Macropinocytosis Positive Thymic T Cell Selection Negative Thymic T Cell Selection Alpha-beta T Cell Proliferation Regulation Of Defense Response To Virus By Virus Positive Regulation Of Phagocytosis
Pathways		Nef and signal transduction Neutrophil degranulation Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Placental abruption ( 29884306) Pneumococcal bacteremia ( 27236921) Prostate cancer ( 29892016) Protein quantitative trait loci ( 18464913)
Interacting Genes		27 interacting genes: CALCOCO2 CCNDBP1 CD247 CRKL ELMO1 HNRNPK KHDRBS1 KHDRBS2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 MDFI MTDH MTUS2 NOTCH2NLA PAK2 PLSCR1 RAC1 RAC2 TRIM23 VAV1
Entrez ID		1794
HPRD ID		09121
Ensembl ID		ENSG00000134516
Uniprot IDs		Q5XG91 Q92608
PDB IDs		2RQR 2YIN 3A98 3B13
Enriched GO Terms of Interacting Partners?
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