ELMO1 and ADGRB3

Number of citations of the paper that reports this interaction (PubMedID 21930703)
15

Data Source:
BioGRID (two hybrid)

		ELMO1	ADGRB3
Description		engulfment and cell motility 1	adhesion G protein-coupled receptor B3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Guanyl-nucleotide Exchange Factor Complex	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Synaptic Cleft Postsynapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding	G Protein-coupled Receptor Activity GTPase Activator Activity Protein Binding
	Biological Process	Phagocytosis, Engulfment Apoptotic Process Cell Migration Rac Protein Signal Transduction Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Regulation Of Defense Response To Virus By Virus	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Myoblast Fusion Neuron Remodeling Negative Regulation Of Angiogenesis Positive Regulation Of GTPase Activity Regulation Of Dendrite Morphogenesis Positive Regulation Of Synapse Assembly Motor Learning Maintenance Of Synapse Structure
Pathways		Nef and signal transduction Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Anticoagulant levels ( 22216198) Body fat mass ( 28552196) Breast size ( 22747683) Celiac disease ( 22057235 20190752 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Cerebrospinal fluid AB1-42 levels ( 28247064) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Height ( 31562340) Inflammatory skin disease ( 25574825) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Mean platelet volume ( 27863252) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Platelet distribution width ( 27863252) Primary biliary cirrhosis ( 22961000) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) QT interval ( 20031603) Response to treatment for acute lymphoblastic leukemia ( 19176441) Rheumatoid arthritis ( 23143596) Sum eosinophil basophil counts ( 27863252) Trunk fat mass ( 28552196) Type 2 diabetes nephropathy ( 17653210)	General risk tolerance (MTAG) ( 30643258) Negative urgency ( 30718321)
Interacting Genes		11 interacting genes: ADGRB1 ADGRB3 APBB1 DOCK1 DOCK2 DOCK5 FGD1 HCK RHOG TRIM54 ZNF398	3 interacting genes: ELMO1 GPATCH11 SNTA1
Entrez ID		9844	577
HPRD ID		12102	04064
Ensembl ID		ENSG00000155849	ENSG00000135298
Uniprot IDs		A4D1X5 Q92556	O60242
PDB IDs		2RQR 2VSZ 3A98	4DLO
Enriched GO Terms of Interacting Partners?
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