DOCK2 and KRTAP9-2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		DOCK2	KRTAP9-2
Description		dedicator of cytokinesis 2	keratin associated protein 9-2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Cytoskeleton Membrane Specific Granule Lumen Extracellular Exosome	Cytosol Keratin Filament
	Molecular Function	GTPase Activator Activity Protein Binding Rac Guanyl-nucleotide Exchange Factor Activity T Cell Receptor Binding	Protein Binding Identical Protein Binding
	Biological Process	Membrane Raft Polarization Establishment Of T Cell Polarity Immunological Synapse Formation Myeloid Dendritic Cell Activation Involved In Immune Response Chemotaxis Small GTPase Mediated Signal Transduction Actin Cytoskeleton Organization Neutrophil Degranulation Positive Regulation Of GTPase Activity Macropinocytosis Positive Thymic T Cell Selection Negative Thymic T Cell Selection Alpha-beta T Cell Proliferation Regulation Of Defense Response To Virus By Virus Positive Regulation Of Phagocytosis	Keratinization
Pathways		Nef and signal transduction Neutrophil degranulation Factors involved in megakaryocyte development and platelet production	Keratinization
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Placental abruption ( 29884306) Pneumococcal bacteremia ( 27236921) Prostate cancer ( 29892016) Protein quantitative trait loci ( 18464913)
Interacting Genes		27 interacting genes: CALCOCO2 CCNDBP1 CD247 CRKL ELMO1 HNRNPK KHDRBS1 KHDRBS2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 MDFI MTDH MTUS2 NOTCH2NLA PAK2 PLSCR1 RAC1 RAC2 TRIM23 VAV1	54 interacting genes: ADAMTSL4 AQP1 ARFGAP1 CATSPER1 CCDC28A CHRD COL8A1 CREB5 DOCK2 FAM76B GATA1 GLRX3 GNE HOXA1 JOSD1 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP26-1 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-4 LCE1B LCE2A LCE3E LCE4A LNX1 MAPKBP1 MEOX2 NOTCH2NLA NTAQ1 NUFIP2 OTX1 PDE9A PLSCR1 PRKAB2 PTPMT1 RCHY1 RNF31 SHFL SMCP SPATA8 SPRY2 SUMO1P1 TMSB10 ZDHHC17
Entrez ID		1794	83899
HPRD ID		09121	13949
Ensembl ID		ENSG00000134516	ENSG00000239886
Uniprot IDs		Q5XG91 Q92608	Q9BYQ4
PDB IDs		2RQR 2YIN 3A98 3B13
Enriched GO Terms of Interacting Partners?
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