ELMO1 and DOCK1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		ELMO1	DOCK1
Description		engulfment and cell motility 1	dedicator of cytokinesis 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Guanyl-nucleotide Exchange Factor Complex	Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Speck Guanyl-nucleotide Exchange Factor Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding
	Biological Process	Phagocytosis, Engulfment Apoptotic Process Cell Migration Rac Protein Signal Transduction Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Regulation Of Defense Response To Virus By Virus	Phagocytosis, Engulfment Apoptotic Process Signal Transduction Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Blood Coagulation Positive Regulation Of Epithelial Cell Migration Cell Migration Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of GTPase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Nef and signal transduction Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation DCC mediated attractive signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Anticoagulant levels ( 22216198) Body fat mass ( 28552196) Breast size ( 22747683) Celiac disease ( 22057235 20190752 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Cerebrospinal fluid AB1-42 levels ( 28247064) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Height ( 31562340) Inflammatory skin disease ( 25574825) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Mean platelet volume ( 27863252) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Platelet distribution width ( 27863252) Primary biliary cirrhosis ( 22961000) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) QT interval ( 20031603) Response to treatment for acute lymphoblastic leukemia ( 19176441) Rheumatoid arthritis ( 23143596) Sum eosinophil basophil counts ( 27863252) Trunk fat mass ( 28552196) Type 2 diabetes nephropathy ( 17653210)	Airway wall thickness ( 25517131) Apolipoprotein Levels ( 23031429) Body mass index ( 25673413) Body mass index (change over time) in gastrointestinal cancer ( 28044437) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) BRCA1/2-negative high-risk breast cancer ( 30323354) Chronotype ( 30696823) Homeostasis model assessment of insulin resistance in less-fat diet ( 30327367) Response to cytidine analogues (gemcitabine) ( 24483146) Response to TNF inhibitor in rheumatoid arthritis (change in disease activity score) ( 30166627) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Social communication problems ( 24564958) Weight ( 28552196)
Interacting Genes		11 interacting genes: ADGRB1 ADGRB3 APBB1 DOCK1 DOCK2 DOCK5 FGD1 HCK RHOG TRIM54 ZNF398	11 interacting genes: BCAR1 CRK CYTH2 ELMO1 ELMO2 NCK2 PRKACA RAC1 RHOG TAMALIN WASF2
Entrez ID		9844	1793
HPRD ID		12102	03240
Ensembl ID		ENSG00000155849	ENSG00000150760
Uniprot IDs		A4D1X5 Q92556	A0A2X0U2H5 B2RUU3 Q14185
PDB IDs		2RQR 2VSZ 3A98	3L4C
Enriched GO Terms of Interacting Partners?
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