EHMT2 and ZNF512B

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		EHMT2	ZNF512B
Description		euchromatic histone lysine methyltransferase 2	zinc finger protein 512B
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Nuclear Speck	Nucleus
	Molecular Function	P53 Binding Protein Binding Zinc Ion Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Histone Methyltransferase Activity (H3-K27 Specific) C2H2 Zinc Finger Domain Binding Promoter-specific Chromatin Binding	DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Replication DNA Methylation Cellular Response To Starvation Histone Methylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Histone H3-K9 Methylation Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Methylation RNA Polymerase I Transcription Initiation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Anti-thyroid drug induced agranulocytosis ( 27157822) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Chronic hepatitis B infection ( 25802187 23760081) Chronotype ( 30696823) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Economic and political preferences (environmentalism) ( 22566634) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 28067908) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Takayasu arteritis ( 25604533) Type 2 diabetes ( 29358691) Ulcerative colitis ( 28067908) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625)	Birth weight ( 31043758) Offspring birth weight ( 31043758) Prostate cancer ( 23535732)
Interacting Genes		48 interacting genes: ABHD17A AURKA CACNA1A CCDC33 CHCHD2 CSNK2A1 CUX1 DNMT3A E4F1 ESR1 FAM161A H1-1 H1-5 H3-3B H3-4 H3C1 H3C14 H3C15 HGS ITGB5 KLF12 KLF3 KLF6 LASP1 LIG1 LIMS1 LMO2 LNX1 MX2 NAA10 NAPRT PLOD3 POR PRRC2B PSMA1 RD3 RELB RERE RPA1 RUVBL2 THAP7 TP53 WIZ XAGE2 ZBTB38 ZNF512B ZNF688 ZNF785	60 interacting genes: ANKLE2 ANKRD28 AP1G1 APLP2 ATRX BRD1 BTBD2 CDC123 CREBZF CTBP2 DCTN1 DDX3X DROSHA DVL3 EHMT2 FHL3 GLRX3 HEYL HTATSF1 IL36RN INVS KDM2A KDM3B KLF10 KMT2B L1TD1 LAMB2 LZTS2 MBD1 MYH10 NIBAN2 OS9 PAPPA2 PBRM1 PDE4DIP PEG10 PIAS4 PLCG2 PPP1R15A PTPRF RPS27A SDF4 SIAH1 SMAD1 SPTBN1 SUPT5H TGM2 TNKS2 TOM1 TOX4 TRAF1 TRAF4 VHL VPS35 VPS41 VWF XPC XRCC6 YES1 ZMYM2
Entrez ID		10919	57473
HPRD ID		06854	13840
Ensembl ID		ENSG00000204371	ENSG00000196700
Uniprot IDs		A0A024RCN9 A2ABF8 B7Z852 Q59FM7 Q96KQ7	Q96KM6
PDB IDs		2O8J 3DM1 3K5K 3RJW 4NVQ 5JHN 5JIN 5JIY 5JJ0 5T0K 5T0M 5TTF 5TUY 5V9I 5VSC 5VSE 6MM1	2GQJ
Enriched GO Terms of Interacting Partners?
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