CLDN3 and POM121

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		CLDN3	POM121
Description		claudin 3	POM121 transmembrane nucleoporin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Integral Component Of Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Protein-containing Complex Apical Junction Complex Tight Junction	Nuclear Envelope Nuclear Pore Nucleoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane Nuclear Membrane Host Cell
	Molecular Function	Transmembrane Signaling Receptor Activity Structural Molecule Activity Protein Binding Identical Protein Binding	Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore
	Biological Process	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Epithelial Cell Morphogenesis Negative Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Establishment Of Endothelial Blood-brain Barrier Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Cell Junction Maintenance Response To Ethanol Negative Regulation Of Wound Healing Bicellular Tight Junction Assembly Positive Regulation Of Wound Healing Regulation Of Membrane Permeability Positive Regulation Of Cell Junction Assembly Positive Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Metallopeptidase Activity	Regulation Of Glycolytic Process RNA Export From Nucleus MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Viral Process Protein Sumoylation Viral Transcription Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat
Pathways		Tight junction interactions	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation
Drugs
Diseases
GWAS		Mean platelet volume ( 27863252) Platelet distribution width ( 27863252)	Subcutaneous adipose tissue ( 22589738)
Interacting Genes		7 interacting genes: APP CLDN1 CLDN5 POM121 PRKACA TJP1 WNK4	21 interacting genes: AGR2 AP2B1 APC ATXN1 BRCA1 CEP55 CEP76 CERT1 CLDN3 FXR2 GFAP GOLGA2 GYG1 HOMER3 LPXN NFKBIA PAXIP1 RBPMS TEX11 TRIM23 TRIP6
Entrez ID		1365	9883
HPRD ID		04219	11448
Ensembl ID		ENSG00000165215	ENSG00000196313
Uniprot IDs		O15551 Q75L79	Q96HA1
PDB IDs			5T6W
Enriched GO Terms of Interacting Partners?
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