POM121 and AGR2

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
HPRD (two hybrid)

		POM121	AGR2
Description		POM121 transmembrane nucleoporin	anterior gradient 2, protein disulphide isomerase family member
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GO Annotations	Cellular Component	Nuclear Envelope Nuclear Pore Nucleoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane Nuclear Membrane Host Cell	Extracellular Space Endoplasmic Reticulum
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore	Dystroglycan Binding Epidermal Growth Factor Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Glycolytic Process RNA Export From Nucleus MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Viral Process Protein Sumoylation Viral Transcription Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat	Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Response To Endoplasmic Reticulum Stress Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive Tract Morphogenesis Positive Regulation Of Developmental Growth Lung Goblet Cell Differentiation Negative Regulation Of Cell Death Mucus Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation
Drugs
Diseases
GWAS		Subcutaneous adipose tissue ( 22589738)	Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Iron status biomarkers (ferritin levels) ( 28334935) Residual cognition ( 28441426) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Interacting Genes		21 interacting genes: AGR2 AP2B1 APC ATXN1 BRCA1 CEP55 CEP76 CERT1 CLDN3 FXR2 GFAP GOLGA2 GYG1 HOMER3 LPXN NFKBIA PAXIP1 RBPMS TEX11 TRIM23 TRIP6	20 interacting genes: APP BRD7 CATSPER1 CCDC90B CKAP2 CRMP1 DAG1 FABP2 GPSM2 KRT31 LYPD3 MED31 MLH1 NRIP1 NUP62CL POM121 RUVBL2 TMEM123 UBQLN1 UBQLN4
Entrez ID		9883	10551
HPRD ID		11448	05896
Ensembl ID		ENSG00000196313	ENSG00000106541
Uniprot IDs		Q96HA1	O95994 Q4JM46
PDB IDs		5T6W	2LNS 2LNT
Enriched GO Terms of Interacting Partners?
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