HEXIM2 and PRDM14

Number of citations of the paper that reports this interaction (PubMedID 21516116)
94

Data Source:
BioGRID (two hybrid)

		HEXIM2	PRDM14
Description		HEXIM P-TEFb complex subunit 2	PR/SET domain 14
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Nucleus Nucleoplasm
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding Identical Protein Binding 7SK SnRNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Methyltransferase Activity Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Cell Fate Specification Inner Cell Mass Cell Fate Commitment Germ Cell Development Embryo Implantation Fertilization Germ-line Stem Cell Population Maintenance Histone H3-R26 Methylation Somatic Stem Cell Population Maintenance Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of DNA Methylation Homeostasis Of Number Of Cells Within A Tissue Inactivation Of Paternal X Chromosome Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Stem Cell Population Maintenance
Pathways			Transcriptional regulation of pluripotent stem cells
Drugs
Diseases
GWAS		Asthma ( 31619474) Craniofacial microsomia ( 26853712) Male-pattern baldness ( 28196072) Systolic blood pressure ( 19430483)	Schizophrenia ( 30285260) Testicular germ cell tumor ( 28604728 28604732 23666240)
Interacting Genes		15 interacting genes: CCNT1 CDK9 GATA1 IHO1 MEOX2 PIM1 PIN1 PRDM14 RNPS1 SPRY1 SPRY2 TADA3 TERF1 TERF2 ZNF250	32 interacting genes: AKAP9 ATPAF2 BAG4 BCAR3 BEX2 CASP8 CDCA7L CHEK2 DGCR6 EED EIF4E2 ERBB2 EZH2 GPATCH2L HEXIM2 HSPB7 ID3 IDH1 MIA3 NDUFB9 PALB2 PAX2 PLEKHF2 PRKAB2 PSMA1 PTPRJ RAD51D RBM10 RCOR3 SUZ12 TEKT4 TTC32
Entrez ID		124790	63978
HPRD ID		08129	11457
Ensembl ID		ENSG00000168517	ENSG00000147596
Uniprot IDs		Q96MH2	Q9GZV8
PDB IDs
Enriched GO Terms of Interacting Partners?
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