PRMT5 and MYOG

Number of citations of the paper that reports this interaction (PubMedID 19188441)
52

Data Source:
BioGRID (pull down)

		PRMT5	MYOG
Description		protein arginine methyltransferase 5	myogenin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Methylosome Histone Methyltransferase Complex	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Protein-DNA Complex
	Molecular Function	P53 Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Methyl-CpG Binding Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Identical Protein Binding Ribonucleoprotein Complex Binding Histone Methyltransferase Activity (H4-R3 Specific) Protein Heterodimerization Activity E-box Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding
	Biological Process	Spliceosomal SnRNP Assembly DNA-templated Transcription, Termination Regulation Of Transcription, DNA-templated Regulation Of Mitotic Nuclear Division Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Circadian Regulation Of Gene Expression Histone Arginine Methylation Peptidyl-arginine N-methylation Endothelial Cell Activation Histone H4-R3 Methylation Regulation Of DNA Methylation Negative Regulation Of Cell Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of ERK1 And ERK2 Cascade Golgi Ribbon Formation Liver Regeneration Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway	Ossification Cell Cycle Skeletal Muscle Tissue Development Negative Regulation Of Cell Proliferation Response To Gravity Positive Regulation Of Myotube Differentiation Skeletal Muscle Atrophy Positive Regulation Of Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Striated Muscle Atrophy Response To Denervation Involved In Regulation Of Muscle Adaptation Skeletal Muscle Cell Differentiation Muscle Cell Fate Commitment MRNA Transcription By RNA Polymerase II Skeletal Muscle Tissue Regeneration Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Fiber Development Positive Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Cycle Arrest Cellular Response To Magnetism Cellular Response To Lithium Ion Cellular Response To Retinoic Acid Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Cellular Response To Estradiol Stimulus Regulation Of Myoblast Fusion Positive Regulation Of Myoblast Fusion Positive Regulation Of Oxidative Phosphorylation
Pathways		snRNP Assembly RMTs methylate histone arginines Regulation of TP53 Activity through Methylation	Myogenesis Myogenesis
Drugs
Diseases
GWAS		Cortical amyloid beta load ( 29860282) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)	Asthma ( 30929738) Asthma (childhood onset) ( 30929738)
Interacting Genes		79 interacting genes: ARGLU1 CALU CAPN1 CCAR2 CDK19 CDK8 CDYL2 CLK1 CLK3 CLNS1A CTDP1 DIO3 DNMT3A DUSP14 EZH2 FAM76B GLI1 GRHL3 GTPBP2 H2AC20 H3-4 H3-5 H3C1 H4-16 H4C1 HOXC4 ILF3 ING5 JAK1 JAK2 JAK3 LDHAL6B LENG8 LUC7L MAGEB2 MBP MCRS1 MEF2D MYOD1 MYOG NCL NELFCD NUDCD2 OLA1 PDGFRA PHYHIP POLR2A PRPF38A RBM23 RSRP1 SF3A3 SIN3A SLU7 SMARCA2 SMARCB1 SMARCC1 SMARCE1 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SREBF1 SSTR1 STUB1 SUPT5H TRIB3 TYK2 UBE3A WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZNF2 ZNF224 ZNF436 ZUP1	36 interacting genes: BBS4 CALM1 CALM2 CALM3 CARM1 CCDC28A CDH18 CLUAP1 CSRP3 EIF4E2 FBXO7 FTL H2AP HNF1A ID1 ID2 ID3 IKBIP MAPK3 MDFI MEF2A MEF2C MLH1 PACRGL POLR2C PRMT5 SEPTIN5 SP1 SRF TAF6L TCF3 TRIM43 TTC25 TTC32 TXNDC9 YME1L1
Entrez ID		10419	4656
HPRD ID		04955	01167
Ensembl ID		ENSG00000100462	ENSG00000122180
Uniprot IDs		B4DV00 O14744	P15173
PDB IDs		4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S
Enriched GO Terms of Interacting Partners?
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