CLCN5 and CFL1

Number of citations of the paper that reports this interaction (PubMedID 12904289)
17

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		CLCN5	CFL1
Description		chloride voltage-gated channel 5	cofilin 1
Image
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Apical Part Of Cell	Extracellular Space Nucleus Cytoplasm Cytosol Cell-cell Junction Focal Adhesion Membrane Nuclear Matrix Lamellipodium Cortical Actin Cytoskeleton Lamellipodium Membrane Vesicle Ruffle Membrane Extracellular Exosome
	Molecular Function	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Solute:proton Antiporter Activity Chloride Ion Binding Identical Protein Binding	Signaling Receptor Binding Protein Binding Actin Filament Binding
	Biological Process	Excretion Ion Transmembrane Transport Chloride Transmembrane Transport Proton Transmembrane Transport	Mitotic Cytokinesis Neural Crest Cell Migration Neural Fold Formation Protein Phosphorylation Cytoskeleton Organization Rho Protein Signal Transduction Response To Virus Regulation Of Cell Morphogenesis Establishment Of Cell Polarity Actin Cytoskeleton Organization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Actin Filament Depolymerization Interleukin-12-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Response To Amino Acid Positive Regulation By Host Of Viral Process Regulation Of Dendritic Spine Morphogenesis
Pathways		Stimuli-sensing channels	Platelet degranulation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion RHO GTPases Activate ROCKs Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			Lauryl Dimethylamine-N-Oxide Copper Artenimol
Diseases		Dent disease, including: Dent disease 1; Dent disease 2; X-linked recessive nephrolithiasis ; Hypophosphatemic rickets; Low-molecular-weight proteinuria with hypercalciuria and nephrocalcinosis
GWAS		Height ( 28552196) Hip circumference adjusted for BMI ( 28552196)	Acne (severe) ( 24927181) Basal cell carcinoma ( 31174203) Breast cancer ( 23535729) DNA methylation (variation) ( 23725790) Keratinocyte cancer (MTAG) ( 31174203) Psoriasis ( 28537254)
Interacting Genes		4 interacting genes: CFL1 MAGI1 WWP1 WWP2	40 interacting genes: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CFL2 CLCN5 EGFR ESR1 HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP NRK POT1 PSEN1 PTEN RAD21 RPS6KA1 SLC2A4 SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 TRIM15 UCHL5 WDR1 YWHAG YWHAQ YWHAZ
Entrez ID		1184	1072
HPRD ID		02053	03261
Ensembl ID		ENSG00000171365	ENSG00000172757
Uniprot IDs		A8K4H5 B3KRR2 P51795 V9GYG7	P23528 V9HWI5
PDB IDs		2J9L 2JA3	1Q8G 1Q8X 3J0S 4BEX 5HVK 5L6W
Enriched GO Terms of Interacting Partners?
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