CFL1 and HSPH1

Number of citations of the paper that reports this interaction (PubMedID 14733918)
2

Data Source:
HPRD (in vitro)

		CFL1	HSPH1
Description		cofilin 1	heat shock protein family H (Hsp110) member 1
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Cell-cell Junction Focal Adhesion Membrane Nuclear Matrix Lamellipodium Cortical Actin Cytoskeleton Lamellipodium Membrane Vesicle Ruffle Membrane Extracellular Exosome	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Protein-containing Complex Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Signaling Receptor Binding Protein Binding Actin Filament Binding	Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Alpha-tubulin Binding
	Biological Process	Mitotic Cytokinesis Neural Crest Cell Migration Neural Fold Formation Protein Phosphorylation Cytoskeleton Organization Rho Protein Signal Transduction Response To Virus Regulation Of Cell Morphogenesis Establishment Of Cell Polarity Actin Cytoskeleton Organization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Actin Filament Depolymerization Interleukin-12-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Response To Amino Acid Positive Regulation By Host Of Viral Process Regulation Of Dendritic Spine Morphogenesis	Receptor-mediated Endocytosis Response To Unfolded Protein Positive Regulation Of MHC Class I Biosynthetic Process Regulation Of Catalytic Activity Chaperone Cofactor-dependent Protein Refolding Positive Regulation Of NK T Cell Activation Regulation Of Cellular Response To Heat
Pathways		Platelet degranulation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion RHO GTPases Activate ROCKs Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Scavenging by Class F Receptors Scavenging by Class F Receptors Regulation of HSF1-mediated heat shock response
Drugs		Lauryl Dimethylamine-N-Oxide Copper Artenimol	Phenethyl Isothiocyanate
Diseases
GWAS		Acne (severe) ( 24927181) Basal cell carcinoma ( 31174203) Breast cancer ( 23535729) DNA methylation (variation) ( 23725790) Keratinocyte cancer (MTAG) ( 31174203) Psoriasis ( 28537254)	Metabolite levels ( 23823483)
Interacting Genes		40 interacting genes: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CFL2 CLCN5 EGFR ESR1 HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP NRK POT1 PSEN1 PTEN RAD21 RPS6KA1 SLC2A4 SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 TRIM15 UCHL5 WDR1 YWHAG YWHAQ YWHAZ	15 interacting genes: ADD1 CFL1 CHD3 CSNK2A1 CSNK2A2 DYNLRB1 HSPA8 NMI PAFAH1B1 PAFAH1B3 PGK1 STK39 TUBA4A UBA1 VAV2
Entrez ID		1072	10808
HPRD ID		03261	09990
Ensembl ID		ENSG00000172757	ENSG00000120694
Uniprot IDs		P23528 V9HWI5	A0A024RDQ0 A0A024RDS1 A0A0A0MSM0 B4DY72 Q92598
PDB IDs		1Q8G 1Q8X 3J0S 4BEX 5HVK 5L6W	6GFA
Enriched GO Terms of Interacting Partners?
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