CFL1 and ACTA2

Number of citations of the paper that reports this interaction (PubMedID 11707283)
2

Data Source:
HPRD (in vitro)

		CFL1	ACTA2
Description		cofilin 1	actin alpha 2, smooth muscle
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Cell-cell Junction Focal Adhesion Membrane Nuclear Matrix Lamellipodium Cortical Actin Cytoskeleton Lamellipodium Membrane Vesicle Ruffle Membrane Extracellular Exosome	Extracellular Space Cytoplasm Cytosol Actin Cytoskeleton Lamellipodium Filopodium Smooth Muscle Contractile Fiber Protein-containing Complex Cell Body Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Actin Filament Binding	ATP Binding Protein Kinase Binding
	Biological Process	Mitotic Cytokinesis Neural Crest Cell Migration Neural Fold Formation Protein Phosphorylation Cytoskeleton Organization Rho Protein Signal Transduction Response To Virus Regulation Of Cell Morphogenesis Establishment Of Cell Polarity Actin Cytoskeleton Organization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Actin Filament Depolymerization Interleukin-12-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Response To Amino Acid Positive Regulation By Host Of Viral Process Regulation Of Dendritic Spine Morphogenesis	Muscle Contraction Regulation Of Blood Pressure Response To Virus Positive Regulation Of Gene Expression Vascular Smooth Muscle Contraction Positive Regulation Of Transcription, DNA-templated Glomerular Mesangial Cell Development Mesenchyme Migration
Pathways		Platelet degranulation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion RHO GTPases Activate ROCKs Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription
Drugs		Lauryl Dimethylamine-N-Oxide Copper Artenimol	Phenethyl Isothiocyanate
Diseases			Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Acne (severe) ( 24927181) Basal cell carcinoma ( 31174203) Breast cancer ( 23535729) DNA methylation (variation) ( 23725790) Keratinocyte cancer (MTAG) ( 31174203) Psoriasis ( 28537254)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia ( 26956414 23770605) Immunoglobulin A ( 20694011) Pulse pressure ( 30578418) Selective IgA deficiency ( 27723758)
Interacting Genes		40 interacting genes: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CFL2 CLCN5 EGFR ESR1 HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP NRK POT1 PSEN1 PTEN RAD21 RPS6KA1 SLC2A4 SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 TRIM15 UCHL5 WDR1 YWHAG YWHAQ YWHAZ	18 interacting genes: CCT4 CCT5 CFL1 CREBBP DNASE1 EP300 GC MINK1 MYL1 MYOC PCYT1B PRKCD SELE SHBG SNTA1 TMSB4X UBE3A YBX1
Entrez ID		1072	59
HPRD ID		03261	00031
Ensembl ID		ENSG00000172757	ENSG00000107796
Uniprot IDs		P23528 V9HWI5	D2JYH4 P62736
PDB IDs		1Q8G 1Q8X 3J0S 4BEX 5HVK 5L6W
Enriched GO Terms of Interacting Partners?
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