CFL1 and MYCBP

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CFL1	MYCBP
Description		cofilin 1	MYC binding protein
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Cell-cell Junction Focal Adhesion Membrane Nuclear Matrix Lamellipodium Cortical Actin Cytoskeleton Lamellipodium Membrane Vesicle Ruffle Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Mitochondrion
	Molecular Function	Signaling Receptor Binding Protein Binding Actin Filament Binding	Transcription Coactivator Activity Protein Binding
	Biological Process	Mitotic Cytokinesis Neural Crest Cell Migration Neural Fold Formation Protein Phosphorylation Cytoskeleton Organization Rho Protein Signal Transduction Response To Virus Regulation Of Cell Morphogenesis Establishment Of Cell Polarity Actin Cytoskeleton Organization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Actin Filament Depolymerization Interleukin-12-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Response To Amino Acid Positive Regulation By Host Of Viral Process Regulation Of Dendritic Spine Morphogenesis	Regulation Of Transcription, DNA-templated Spermatogenesis Positive Regulation Of Nucleic Acid-templated Transcription
Pathways		Platelet degranulation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion RHO GTPases Activate ROCKs Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Lauryl Dimethylamine-N-Oxide Copper Artenimol
Diseases
GWAS		Acne (severe) ( 24927181) Basal cell carcinoma ( 31174203) Breast cancer ( 23535729) DNA methylation (variation) ( 23725790) Keratinocyte cancer (MTAG) ( 31174203) Psoriasis ( 28537254)	Beard thickness ( 26926045) Blood protein levels ( 28240269) Menopause (age at onset) ( 26414677)
Interacting Genes		40 interacting genes: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CFL2 CLCN5 EGFR ESR1 HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP NRK POT1 PSEN1 PTEN RAD21 RPS6KA1 SLC2A4 SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 TRIM15 UCHL5 WDR1 YWHAG YWHAQ YWHAZ	15 interacting genes: AKAP1 ARHGEF40 CFAP91 CFL1 COPS6 CPNE1 CPNE2 CPNE4 DISP3 GDF9 MYC MYCBPAP PTN SSRP1 UBC
Entrez ID		1072	26292
HPRD ID		03261	08406
Ensembl ID		ENSG00000172757	ENSG00000214114
Uniprot IDs		P23528 V9HWI5	Q99417
PDB IDs		1Q8G 1Q8X 3J0S 4BEX 5HVK 5L6W	2YY0
Enriched GO Terms of Interacting Partners?
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