WWOX and CPSF2

Number of citations of the paper that reports this interaction (PubMedID 16055720)
81

Data Source:
BioGRID (pull down, affinity chromatography technology)

		WWOX	CPSF2
Description		WW domain containing oxidoreductase	cleavage and polyadenylation specific factor 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Microvillus RNA Polymerase II Transcription Factor Complex	Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding Oxidoreductase Activity Enzyme Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Skeletal System Morphogenesis Oxidation-reduction Process Cellular Response To Transforming Growth Factor Beta Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	MRNA Splicing, Via Spliceosome Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Cleavage MRNA 3'-end Processing By Stem-loop Binding And Cleavage MRNA Export From Nucleus MRNA 3'-end Processing
Pathways		Nuclear signaling by ERBB4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors	Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Alzheimer's disease (late onset) ( 30820047) Anorexia nervosa ( 23568457) Bipolar disorder (body mass index interaction) ( 24322204) Brain volume in infants (white matter) ( 28763065) Cardiac structure and function ( 19584346) Clozapine-induced cytotoxicity ( 25656473) Colorectal cancer ( 30529582 29228715) Daytime sleep phenotypes ( 27126917) Diffusing capacity of carbon monoxide ( 30694715) Early-onset Parkinson's disease ( 28256260) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Familial squamous cell lung carcinoma ( 29924316) FEV1 ( 30804560) Hip shape (DXA scan) ( 30320955) Idiopathic dilated cardiomyopathy ( 29495422) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Metabolite levels ( 23823483) Metabolite levels (5-HIAA) ( 23319000) Molybdenum levels ( 26025379) Multiple sclerosis ( 31604244 24076602) Obesity ( 21552555) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Peak expiratory flow ( 30804560) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Radiation response ( 20923822) Response to amphetamines ( 22952603) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Serum thyroid-stimulating hormone levels ( 25436638) Serum uric acid levels in response to allopurinol in gout ( 25676789) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Systemic juvenile idiopathic arthritis ( 27927641) Type 2 diabetes ( 22158537) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	3-month functional outcome in lacunar ischaemic stroke (modified Rankin score) ( 30796134) B cell acute lymphoblastic leukaemia (hyperdiploid negative) ( 29296818) B cell acute lymphoblastic leukaemia (normal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) ( 29296818) Dialysis-related mortality ( 21546767) Height ( 18391951) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Monobrow ( 27182965) Myopia ( 27182965) Obesity-related traits ( 23251661)
Interacting Genes		25 interacting genes: APBB2 CLNK CPSF2 CPSF7 ERBB4 EZR FIP1L1 HNRNPK HYAL2 LATS1 MAPK8 NUDT21 SCAMP3 SEC23IP SF3B3 SMAD4 SRC TCERG1 TFAP2C TNK2 TP53 TP73 UBB WDR33 WIPF2	2 interacting genes: POLR2A WWOX
Entrez ID		51741	53981
HPRD ID		05501	05824
Ensembl ID		ENSG00000186153	ENSG00000165934
Uniprot IDs		A0A411HBC7 Q9NZC7	A0A024R6H0 Q9P2I0
PDB IDs		1WMV	6URG
Enriched GO Terms of Interacting Partners?
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