OSR2 and CRBN

Number of citations of the paper that reports this interaction (PubMedID 30385546)
17

Data Source:
BioGRID (pull down)

		OSR2	CRBN
Description		odd-skipped related transciption factor 2	cereblon
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding	Protein Binding Ion Channel Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Urogenital System Development Metanephros Development Mesonephros Development Chondrocyte Differentiation Positive Regulation Of Cell Proliferation Embryo Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Bone Mineralization Osteoblast Proliferation Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Skeletal Limb Joint Morphogenesis Middle Ear Morphogenesis Odontogenesis Embryonic Digit Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Roof Of Mouth Development Embryonic Skeletal Joint Morphogenesis Head Development Bone Morphogenesis Eyelid Development In Camera-type Eye Embryonic Skeletal Joint Development	Protein Ubiquitination Negative Regulation Of Protein Complex Assembly Positive Regulation Of Protein Complex Assembly Negative Regulation Of Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs			Lenalidomide Thalidomide Pomalidomide
Diseases			Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 29403010 27863252) White matter integrity ( 23218918)
Interacting Genes		2 interacting genes: CRBN PSMA3	33 interacting genes: APPL2 BCL6 BCL6B BSG CSNK1A1 EGR1 EGR4 GLUL GRB2 GSPT1 GZF1 HIC1 HIC2 IKZF3 KDM1A OSR1 OSR2 PAK5 PIK3R3 RBPMS RBX1 SALL1 SALL3 SALL4 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 WIZ ZBTB7A ZBTB7B ZFP91
Entrez ID		116039	51185
HPRD ID		17806	16750
Ensembl ID		ENSG00000164920	ENSG00000113851
Uniprot IDs		Q8N2R0	Q96SW2
PDB IDs			4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?