TRIM63 and PDHB

Number of citations of the paper that reports this interaction (PubMedID 18468620)
27

Data Source:
HPRD (two hybrid)

		TRIM63	PDHB
Description		tripartite motif containing 63	pyruvate dehydrogenase E1 subunit beta
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GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Z Disc M Band	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Pyruvate Dehydrogenase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Titin Binding	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity
	Biological Process	Muscle Contraction Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Response To Glucocorticoid Response To Interleukin-1	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate
Pathways		FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation	Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism
Drugs			Pyruvic acid NADH
Diseases			Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS			Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) IgG levels ( 28628107) Systemic lupus erythematosus ( 26502338 28714469) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) vWF levels ( 30586737)
Interacting Genes		93 interacting genes: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5F1B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH HSPD1 JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYH6 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP THRA TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2J1 UBE2K UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1	16 interacting genes: AKT1 ANXA7 CDKN1A FCER1A GNB2 GRB7 HSD17B10 ITGB1 PDHA1 PDHA2 PDHX PFDN1 RAP1B RCC1 TRIM63 TSC22D1
Entrez ID		84676	5162
HPRD ID		05843	01530
Ensembl ID		ENSG00000158022	ENSG00000168291
Uniprot IDs		Q969Q1	A0A384MDR8 P11177
PDB IDs		2D8U 3DDT 4M3L	1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO
Enriched GO Terms of Interacting Partners?
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