FCHO2 and EPS15

Number of citations of the paper that reports this interaction (PubMedID 27237791)
24

Data Source:
BioGRID (pull down)

		FCHO2	EPS15
Description		FCH and mu domain containing endocytic adaptor 2	epidermal growth factor receptor pathway substrate 15
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Clathrin-coated Vesicle Presynaptic Endocytic Zone Membrane	Cytosol Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Membrane Aggresome Apical Plasma Membrane AP-2 Adaptor Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Ciliary Membrane Postsynapse Glutamatergic Synapse
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Phosphatidylinositol Binding Identical Protein Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Cadherin Binding
	Biological Process	Membrane Invagination Clathrin Coat Assembly Synaptic Vesicle Endocytosis Membrane Organization Clathrin-dependent Endocytosis Protein Localization To Plasma Membrane	Positive Regulation Of Receptor Recycling Golgi To Endosome Transport Vesicle Organization Receptor-mediated Endocytosis Of Virus By Host Cell Endocytic Recycling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Proliferation Viral Entry Into Host Cell Clathrin Coat Assembly Membrane Organization Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Aspartate aminotransferase levels ( 29403010) Discordance in emotional problems in monozygotic twins ( 27043157) Eyebrow thickness ( 26926045) Factor VIII levels ( 30586737) Heel bone mineral density ( 30598549) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Monobrow thickness ( 26926045) Non-albumin protein levels ( 29403010) Red cell distribution width ( 27863252) Serum albumin level ( 29403010) Small cell lung carcinoma ( 28604730) vWF levels ( 30586737)	Blood urea nitrogen levels ( 31152163) IgE grass sensitization ( 22036096) PR interval ( 30046033)
Interacting Genes		7 interacting genes: DAB2 EPS15 EPS15L1 ITSN1 MRPS27 RHOU UBC	51 interacting genes: AGFG1 AGFG2 AP1G1 AP2A1 AP2A2 CLINT1 CORO7 CRK DNM1 DNM2 EGFR ELF3 EPN1 EPN2 FCHO1 FCHO2 GRB2 HGS ITSN1 LAPTM5 MAPK14 MOB4 MTNR1A NAGPA NEDD4 NUMB NUMBL OPTN PPT1 PRKN REPS2 RNF11 SCAMP1 SGIP1 SNAP91 SPART SPOPL STAM2 STAMBP STON2 SYNJ1 TFAP2A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1 USP8
Entrez ID		115548	2060
HPRD ID		13319	08968
Ensembl ID		ENSG00000157107	ENSG00000085832
Uniprot IDs		Q0JRZ9	B7Z240 P42566
PDB IDs		2V0O	1C07 1EH2 1F8H 1FF1 2IV9 2JXC 4RH5 4RH9 4RHG 4S0G 5AWT 5AWU 5JP2
Enriched GO Terms of Interacting Partners?
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