EPS15 and SYNJ1

Number of citations of the paper that reports this interaction (PubMedID 9428629)
41

Data Source:
HPRD (in vitro)

		EPS15	SYNJ1
Description		epidermal growth factor receptor pathway substrate 15	synaptojanin 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Membrane Aggresome Apical Plasma Membrane AP-2 Adaptor Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Ciliary Membrane Postsynapse Glutamatergic Synapse	Cell Cytosol Microtubule Vesicle Membrane Membrane Coat Clathrin Coat Of Coated Pit Terminal Bouton Perinuclear Region Of Cytoplasm Synaptic Membrane Presynapse
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Cadherin Binding	RNA Binding Phosphatidylinositol-3-phosphatase Activity Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity SH3 Domain Binding Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity
	Biological Process	Positive Regulation Of Receptor Recycling Golgi To Endosome Transport Vesicle Organization Receptor-mediated Endocytosis Of Virus By Host Cell Endocytic Recycling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Proliferation Viral Entry Into Host Cell Clathrin Coat Assembly Membrane Organization Postsynaptic Neurotransmitter Receptor Internalization	Phosphatidylinositol Biosynthetic Process Neurotransmitter Transport Brain Development Learning Synaptic Vesicle Priming Synaptic Vesicle Uncoating Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Membrane Organization Positive Regulation Of Endosome Organization
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	Synthesis of PIPs at the plasma membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) IgE grass sensitization ( 22036096) PR interval ( 30046033)
Interacting Genes		51 interacting genes: AGFG1 AGFG2 AP1G1 AP2A1 AP2A2 CLINT1 CORO7 CRK DNM1 DNM2 EGFR ELF3 EPN1 EPN2 FCHO1 FCHO2 GRB2 HGS ITSN1 LAPTM5 MAPK14 MOB4 MTNR1A NAGPA NEDD4 NUMB NUMBL OPTN PPT1 PRKN REPS2 RNF11 SCAMP1 SGIP1 SNAP91 SPART SPOPL STAM2 STAMBP STON2 SYNJ1 TFAP2A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1 USP8	23 interacting genes: AMPH AP2A1 AP2M1 BIN1 CDK5 CLTA CLTC EPHB2 EPS15 FNBP4 GRB2 ITSN1 PACSIN1 PACSIN2 PACSIN3 PPP3CA SH3BP1 SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SH3KBP1 SORBS2
Entrez ID		2060	8867
HPRD ID		08968	09182
Ensembl ID		ENSG00000085832	ENSG00000159082
Uniprot IDs		B7Z240 P42566	A0A0D9SGJ6 B9EGN3 C9JFZ1 J3KQV8 O43426 Q05CZ1
PDB IDs		1C07 1EH2 1F8H 1FF1 2IV9 2JXC 4RH5 4RH9 4RHG 4S0G 5AWT 5AWU 5JP2	1W80 2DNR 2VJ0
Enriched GO Terms of Interacting Partners?
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