EPS15 and REPS2

Number of citations of the paper that reports this interaction (PubMedID 10393179)
69

Data Source:
BioGRID (affinity chromatography technology, far western blotting)
HPRD (in vitro)

		EPS15	REPS2
Description		epidermal growth factor receptor pathway substrate 15	RALBP1 associated Eps domain containing 2
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Membrane Aggresome Apical Plasma Membrane AP-2 Adaptor Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Ciliary Membrane Postsynapse Glutamatergic Synapse	Cytosol
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Cadherin Binding	Calcium Ion Binding Protein Binding
	Biological Process	Positive Regulation Of Receptor Recycling Golgi To Endosome Transport Vesicle Organization Receptor-mediated Endocytosis Of Virus By Host Cell Endocytic Recycling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Proliferation Viral Entry Into Host Cell Clathrin Coat Assembly Membrane Organization Postsynaptic Neurotransmitter Receptor Internalization	Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization Protein-containing Complex Assembly
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) IgE grass sensitization ( 22036096) PR interval ( 30046033)
Interacting Genes		51 interacting genes: AGFG1 AGFG2 AP1G1 AP2A1 AP2A2 CLINT1 CORO7 CRK DNM1 DNM2 EGFR ELF3 EPN1 EPN2 FCHO1 FCHO2 GRB2 HGS ITSN1 LAPTM5 MAPK14 MOB4 MTNR1A NAGPA NEDD4 NUMB NUMBL OPTN PPT1 PRKN REPS2 RNF11 SCAMP1 SGIP1 SNAP91 SPART SPOPL STAM2 STAMBP STON2 SYNJ1 TFAP2A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1 USP8	13 interacting genes: AR ASAP1 ASAP2 CDK1 CDK5RAP2 EPN1 EPS15 GRB2 PXN RALB RALBP1 RELA REPS1
Entrez ID		2060	9185
HPRD ID		08968	02262
Ensembl ID		ENSG00000085832	ENSG00000169891
Uniprot IDs		B7Z240 P42566	Q8NFH8
PDB IDs		1C07 1EH2 1F8H 1FF1 2IV9 2JXC 4RH5 4RH9 4RHG 4S0G 5AWT 5AWU 5JP2	1IQ3
Enriched GO Terms of Interacting Partners?
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