RHPN1 and EFEMP2

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RHPN1	EFEMP2
Description		rhophilin Rho GTPase binding protein 1	EGF containing fibulin extracellular matrix protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Extracellular Region Basement Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Extracellular Vesicle
	Molecular Function	Protein Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Signal Transduction	Elastic Fiber Assembly
Pathways		RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases			Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS			Acne (severe) ( 24927181) Birth weight ( 31043758)
Interacting Genes		10 interacting genes: CALCOCO2 CEP70 CNKSR1 EFEMP2 KRT15 MTUS2 RHOA ROPN1 TRIM27 TRIM37	52 interacting genes: AMMECR1 APEX2 AQP1 ATN1 ATXN1 ATXN7 BAG6 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK COL8A1 CREB5 DGCR6 FAM107A FAM124B FAM74A4 GFI1B GLRX3 HDAC4 HHEX HOXA1 IL16 LCE2D LCE3C LINGO1 MEOX2 NEDD4L NOS3 NUFIP2 PIDD1 PLSCR1 PLSCR4 PRPF31 PTGER3 RBPMS RERE RHOXF2 RHPN1 RIBC2 SGTA SGTB STK16 TCAF1 TP53 UBQLN1 UBQLN4 ZNF263 ZNF426 ZNF638
Entrez ID		114822	30008
HPRD ID		17973	05221
Ensembl ID		ENSG00000158106	ENSG00000172638
Uniprot IDs		Q8TCX5	A0A024R5G1 O95967 Q9H3D5
PDB IDs			2KL7
Enriched GO Terms of Interacting Partners?
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