HELQ and RIPK3

Number of citations of the paper that reports this interaction (PubMedID 29883609)
4

Data Source:
BioGRID (pull down)

		HELQ	RIPK3
Description		helicase, POLQ like	receptor interacting serine/threonine kinase 3
Image		No pdb structure
GO Annotations	Cellular Component		Mitochondrion Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	DNA Binding DNA Helicase Activity Protein Binding ATP Binding	Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Maturation Of SSU-rRNA DNA Duplex Unwinding	Regulation Of T Cell Mediated Cytotoxicity Regulation Of Adaptive Immune Response Cellular Protein Modification Process Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Phosphatase Activity Activation Of Protein Kinase Activity Regulation Of Interferon-gamma Production T Cell Differentiation In Thymus NIK/NF-kappaB Signaling T Cell Homeostasis Regulation Of Activated T Cell Proliferation Protein Autophosphorylation Lymph Node Development Spleen Development Thymus Development Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Ligase Activity Positive Regulation Of Oxidoreductase Activity Positive Regulation Of Necroptotic Process Regulation Of Activation-induced Cell Death Of T Cells Necroptotic Process Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of Nucleic Acid-templated Transcription Amyloid Fibril Formation Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels RIPK1-mediated regulated necrosis TLR3-mediated TICAM1-dependent programmed cell death IKK complex recruitment mediated by RIP1
Drugs
Diseases
GWAS		Age-related cognitive decline (executive function) (slope of z-scores) ( 30954325) Breast cancer ( 29059683) Menopause (age at onset) ( 22267201 26414677 29773799)	Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549)
Interacting Genes		1 interacting genes: RIPK3	22 interacting genes: BIRC2 BIRC3 BUB1B DAXX GBE1 H1-5 HELQ HSPBAP1 IL24 NME8 PELI1 RFX6 RIPK1 SRPK2 TICAM1 TLE6 TMEM44 TNFRSF1A TRAF2 UTP11 XIAP ZSCAN20
Entrez ID		113510	11035
HPRD ID		08422	09315
Ensembl ID		ENSG00000163312	ENSG00000129465
Uniprot IDs		Q8TDG4	Q9Y572
PDB IDs			5V7Z
Enriched GO Terms of Interacting Partners?
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