RIPK3

Description		receptor interacting serine/threonine kinase 3
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GO Annotations	Cellular Component	Mitochondrion Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Regulation Of T Cell Mediated Cytotoxicity Regulation Of Adaptive Immune Response Cellular Protein Modification Process Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Phosphatase Activity Activation Of Protein Kinase Activity Regulation Of Interferon-gamma Production T Cell Differentiation In Thymus NIK/NF-kappaB Signaling T Cell Homeostasis Regulation Of Activated T Cell Proliferation Protein Autophosphorylation Lymph Node Development Spleen Development Thymus Development Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Ligase Activity Positive Regulation Of Oxidoreductase Activity Positive Regulation Of Necroptotic Process Regulation Of Activation-induced Cell Death Of T Cells Necroptotic Process Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of Nucleic Acid-templated Transcription Amyloid Fibril Formation Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels RIPK1-mediated regulated necrosis TLR3-mediated TICAM1-dependent programmed cell death IKK complex recruitment mediated by RIP1
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549)
Interacting Genes		22 interacting genes: BIRC2 BIRC3 BUB1B DAXX GBE1 H1-5 HELQ HSPBAP1 IL24 NME8 PELI1 RFX6 RIPK1 SRPK2 TICAM1 TLE6 TMEM44 TNFRSF1A TRAF2 UTP11 XIAP ZSCAN20
Entrez ID		11035
HPRD ID		09315
Ensembl ID		ENSG00000129465
Uniprot IDs		Q9Y572
PDB IDs		5V7Z
Enriched GO Terms of Interacting Partners?
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