RIPK3 and PELI1

Number of citations of the paper that reports this interaction (PubMedID 29883609)
4

Data Source:
BioGRID (enzymatic study)

		RIPK3	PELI1
Description		receptor interacting serine/threonine kinase 3	pellino E3 ubiquitin protein ligase 1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Plasma Membrane Protein-containing Complex	Condensed Nuclear Chromosome Kinetochore Cytosol
	Molecular Function	Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein-containing Complex Binding	Protein Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of T Cell Mediated Cytotoxicity Regulation Of Adaptive Immune Response Cellular Protein Modification Process Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Phosphatase Activity Activation Of Protein Kinase Activity Regulation Of Interferon-gamma Production T Cell Differentiation In Thymus NIK/NF-kappaB Signaling T Cell Homeostasis Regulation Of Activated T Cell Proliferation Protein Autophosphorylation Lymph Node Development Spleen Development Thymus Development Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Ligase Activity Positive Regulation Of Oxidoreductase Activity Positive Regulation Of Necroptotic Process Regulation Of Activation-induced Cell Death Of T Cells Necroptotic Process Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of Nucleic Acid-templated Transcription Amyloid Fibril Formation Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Protein Polyubiquitination Positive Regulation Of Cytokine Production Toll Signaling Pathway Regulation Of Toll Signaling Pathway Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of T Cell Proliferation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To DsRNA Negative Regulation Of Necroptotic Process Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination
Pathways		TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels RIPK1-mediated regulated necrosis TLR3-mediated TICAM1-dependent programmed cell death IKK complex recruitment mediated by RIP1	Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549)	Allergic dermatitis (nickel) ( 23921680) Kawasaki disease ( 21221998)
Interacting Genes		22 interacting genes: BIRC2 BIRC3 BUB1B DAXX GBE1 H1-5 HELQ HSPBAP1 IL24 NME8 PELI1 RFX6 RIPK1 SRPK2 TICAM1 TLE6 TMEM44 TNFRSF1A TRAF2 UTP11 XIAP ZSCAN20	23 interacting genes: BCL6 BIRC3 BUB1B IKBKB IRAK1 IRAK2 IRAK4 IRS1 MDM4 RIPK1 RIPK3 SRPK1 SRPK2 TP53 TRIP13 UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2V1 VAC14
Entrez ID		11035	57162
HPRD ID		09315	17834
Ensembl ID		ENSG00000129465	ENSG00000197329
Uniprot IDs		Q9Y572	Q53T26 Q96FA3
PDB IDs		5V7Z
Enriched GO Terms of Interacting Partners?
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