RIPK3 and HELQ

Number of citations of the paper that reports this interaction (PubMedID 29883609)
4

Data Source:
BioGRID (pull down)

		RIPK3	HELQ
Description		receptor interacting serine/threonine kinase 3	helicase, POLQ like
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein-containing Complex Binding	DNA Binding DNA Helicase Activity Protein Binding ATP Binding
	Biological Process	Regulation Of T Cell Mediated Cytotoxicity Regulation Of Adaptive Immune Response Cellular Protein Modification Process Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Phosphatase Activity Activation Of Protein Kinase Activity Regulation Of Interferon-gamma Production T Cell Differentiation In Thymus NIK/NF-kappaB Signaling T Cell Homeostasis Regulation Of Activated T Cell Proliferation Protein Autophosphorylation Lymph Node Development Spleen Development Thymus Development Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Ligase Activity Positive Regulation Of Oxidoreductase Activity Positive Regulation Of Necroptotic Process Regulation Of Activation-induced Cell Death Of T Cells Necroptotic Process Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of Nucleic Acid-templated Transcription Amyloid Fibril Formation Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Double-strand Break Repair Via Homologous Recombination Maturation Of SSU-rRNA DNA Duplex Unwinding
Pathways		TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels RIPK1-mediated regulated necrosis TLR3-mediated TICAM1-dependent programmed cell death IKK complex recruitment mediated by RIP1
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549)	Age-related cognitive decline (executive function) (slope of z-scores) ( 30954325) Breast cancer ( 29059683) Menopause (age at onset) ( 22267201 26414677 29773799)
Interacting Genes		22 interacting genes: BIRC2 BIRC3 BUB1B DAXX GBE1 H1-5 HELQ HSPBAP1 IL24 NME8 PELI1 RFX6 RIPK1 SRPK2 TICAM1 TLE6 TMEM44 TNFRSF1A TRAF2 UTP11 XIAP ZSCAN20	1 interacting genes: RIPK3
Entrez ID		11035	113510
HPRD ID		09315	08422
Ensembl ID		ENSG00000129465	ENSG00000163312
Uniprot IDs		Q9Y572	Q8TDG4
PDB IDs		5V7Z
Enriched GO Terms of Interacting Partners?
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