RIPK3 and RFX6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		RIPK3	RFX6
Description		receptor interacting serine/threonine kinase 3	regulatory factor X6
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Plasma Membrane Protein-containing Complex	Nuclear Chromatin Nucleus
	Molecular Function	Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein-containing Complex Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding
	Biological Process	Regulation Of T Cell Mediated Cytotoxicity Regulation Of Adaptive Immune Response Cellular Protein Modification Process Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Phosphatase Activity Activation Of Protein Kinase Activity Regulation Of Interferon-gamma Production T Cell Differentiation In Thymus NIK/NF-kappaB Signaling T Cell Homeostasis Regulation Of Activated T Cell Proliferation Protein Autophosphorylation Lymph Node Development Spleen Development Thymus Development Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Ligase Activity Positive Regulation Of Oxidoreductase Activity Positive Regulation Of Necroptotic Process Regulation Of Activation-induced Cell Death Of T Cells Necroptotic Process Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of Nucleic Acid-templated Transcription Amyloid Fibril Formation Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Pancreatic D Cell Differentiation Regulation Of Transcription By RNA Polymerase II Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Secretion Pancreatic Epsilon Cell Differentiation
Pathways		TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels RIPK1-mediated regulated necrosis TLR3-mediated TICAM1-dependent programmed cell death IKK complex recruitment mediated by RIP1	Regulation of gene expression in beta cells
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549)	Chronic obstructive pulmonary disease ( 30804561) Creatine kinase levels ( 29403010) Diastolic blood pressure ( 27841878) Height ( 31562340) Inflammatory bowel disease ( 27569725) Lung cancer ( 28604730) Neutrophil percentage of granulocytes ( 27863252) Offspring birth weight ( 31043758) Prostate cancer ( 20676098 31562322 26443449) Serum total protein level ( 29403010)
Interacting Genes		22 interacting genes: BIRC2 BIRC3 BUB1B DAXX GBE1 H1-5 HELQ HSPBAP1 IL24 NME8 PELI1 RFX6 RIPK1 SRPK2 TICAM1 TLE6 TMEM44 TNFRSF1A TRAF2 UTP11 XIAP ZSCAN20	27 interacting genes: ARNT2 CATSPER1 CCNK CYFIP1 DGCR6 DTX2 ESR2 FHL3 FRS3 HGS KIF1A LMO3 NEDD9 PITX1 PLEKHN1 PRKAA1 PRKAA2 RFX2 RFX3 RIPK3 SNRPB SNRPC SS18L1 STK16 TLE5 VPS37C ZNF688
Entrez ID		11035	222546
HPRD ID		09315	11490
Ensembl ID		ENSG00000129465	ENSG00000185002
Uniprot IDs		Q9Y572	Q8HWS3
PDB IDs		5V7Z
Enriched GO Terms of Interacting Partners?
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