ZHX1 and TARDBP

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		ZHX1	TARDBP
Description		zinc fingers and homeoboxes 1	TAR DNA binding protein
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasmic Stress Granule Nuclear Speck Interchromatin Granule Ribonucleoprotein Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding Protein Heterodimerization Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity RNA Binding MRNA 3'-UTR Binding Protein Binding Identical Protein Binding Sequence-specific DNA Binding Pre-mRNA Intronic Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II MRNA Processing RNA Splicing Negative Regulation Of Gene Expression Regulation Of Protein Stability Positive Regulation Of Insulin Secretion Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Negative Regulation By Host Of Viral Transcription Rhythmic Process Regulation Of RNA Metabolic Process Regulation Of Cell Cycle 3'-UTR-mediated MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Nuclear Inner Membrane Organization
Pathways
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS			Beard thickness ( 26926045) Ewing sarcoma ( 22327514) Male-pattern baldness ( 22693459 28196072)
Interacting Genes		53 interacting genes: AKR1C3 AKT1 ATXN1 BARD1 BCL2L1 BHLHE40 BID CHD3 CREB1 CREBBP CSNK2A1 DDX39B DLST DYNLL1 EFNA2 ELL GADD45A GNG11 GSK3B HSPE1 IDH1 LAMA4 LYAR MPHOSPH6 NACA NFYA PAFAH1B3 PEX14 PIAS4 PIGC PNP PRPF40A PSMD11 SAT1 SERPINB9 SUMO1 SUMO2 TAL1 TALDO1 TARDBP TERF1 TNFRSF10C TOLLIP TP53 UBC UTP3 VIM WDR33 ZHX2 ZHX3 ZMYND11 ZNF33B ZYX	17 interacting genes: APP EXOSC10 FBXO7 FUS IRAK2 LSM6 MED6 NACC1 NSFL1C RACK1 RBM45 RNF2 SETDB1 UBQLN1 XRN2 ZFAND2B ZHX1
Entrez ID		11244	23435
HPRD ID		10379	05466
Ensembl ID		ENSG00000165156	ENSG00000120948
Uniprot IDs		A0A024R9F1 Q9UKY1	A0A024R4E2 Q13148 Q9H256
PDB IDs		2ECB 2GHF 2LY9 3NAR	1WF0 2CQG 2N2C 2N3X 2N4G 2N4H 2N4P 4BS2 4IUF 4Y00 4Y0F 5MDI 5MRG 5W50 5W52 5W7V 5WHN 5WHP 5WIA 5WIQ 5WKB 5WKD 5X4F 6B1G 6CF4 6CFH 6N37 6N3A 6N3B 6N3C
Enriched GO Terms of Interacting Partners?
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