TARDBP and LSM6

Number of citations of the paper that reports this interaction (PubMedID 24825905)
21

Data Source:
BioGRID (two hybrid)

		TARDBP	LSM6
Description		TAR DNA binding protein	LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasmic Stress Granule Nuclear Speck Interchromatin Granule Ribonucleoprotein Complex	P-body Nucleus Nucleoplasm U6 SnRNP Nucleolus Small Nucleolar Ribonucleoprotein Complex Cytoplasm Cytosol Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Lsm2-8 Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity RNA Binding MRNA 3'-UTR Binding Protein Binding Identical Protein Binding Sequence-specific DNA Binding Pre-mRNA Intronic Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II MRNA Processing RNA Splicing Negative Regulation Of Gene Expression Regulation Of Protein Stability Positive Regulation Of Insulin Secretion Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Negative Regulation By Host Of Viral Transcription Rhythmic Process Regulation Of RNA Metabolic Process Regulation Of Cell Cycle 3'-UTR-mediated MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Nuclear Inner Membrane Organization	MRNA Splicing, Via Spliceosome MRNA Catabolic Process TRNA Processing RNA Splicing Maturation Of SSU-rRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways			mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs			Uridine Uridine monophosphate Citric Acid
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Beard thickness ( 26926045) Ewing sarcoma ( 22327514) Male-pattern baldness ( 22693459 28196072)	Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)
Interacting Genes		17 interacting genes: APP EXOSC10 FBXO7 FUS IRAK2 LSM6 MED6 NACC1 NSFL1C RACK1 RBM45 RNF2 SETDB1 UBQLN1 XRN2 ZFAND2B ZHX1	14 interacting genes: APP LSM1 LSM2 LSM3 LSM5 LSM7 LSM8 MCRS1 POLD2 SDCBP SMN1 SNRPD2 SNRPF TARDBP
Entrez ID		23435	11157
HPRD ID		05466	06286
Ensembl ID		ENSG00000120948	ENSG00000164167
Uniprot IDs		A0A024R4E2 Q13148 Q9H256	P62312
PDB IDs		1WF0 2CQG 2N2C 2N3X 2N4G 2N4H 2N4P 4BS2 4IUF 4Y00 4Y0F 5MDI 5MRG 5W50 5W52 5W7V 5WHN 5WHP 5WIA 5WIQ 5WKB 5WKD 5X4F 6B1G 6CF4 6CFH 6N37 6N3A 6N3B 6N3C	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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