ZHX1 and IDH1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZHX1	IDH1
Description		zinc fingers and homeoboxes 1	isocitrate dehydrogenase (NADP(+)) 1
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Extracellular Region Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Secretory Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding Protein Heterodimerization Activity	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity Identical Protein Binding Protein Homodimerization Activity Cadherin Binding NADP Binding NAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of Transcription, DNA-templated	Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process Protein Targeting To Peroxisome NADP Metabolic Process NADPH Regeneration Glutathione Metabolic Process Response To Oxidative Stress Female Gonad Development Neutrophil Degranulation Response To Steroid Hormone Regulation Of Phospholipid Catabolic Process Regulation Of Phospholipid Biosynthetic Process
Pathways			Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate NADPH regeneration Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import
Drugs			Isocitric Acid 2'-Monophosphoadenosine 5'-Diphosphoribose
Diseases
GWAS			Cerebral amyloid deposition (PET imaging) ( 30361487) Glioma ( 28346443) Non-glioblastoma glioma ( 28346443)
Interacting Genes		53 interacting genes: AKR1C3 AKT1 ATXN1 BARD1 BCL2L1 BHLHE40 BID CHD3 CREB1 CREBBP CSNK2A1 DDX39B DLST DYNLL1 EFNA2 ELL GADD45A GNG11 GSK3B HSPE1 IDH1 LAMA4 LYAR MPHOSPH6 NACA NFYA PAFAH1B3 PEX14 PIAS4 PIGC PNP PRPF40A PSMD11 SAT1 SERPINB9 SUMO1 SUMO2 TAL1 TALDO1 TARDBP TERF1 TNFRSF10C TOLLIP TP53 UBC UTP3 VIM WDR33 ZHX2 ZHX3 ZMYND11 ZNF33B ZYX	14 interacting genes: AGGF1 CRACR2B DKK3 FAM131A FHL2 FIGNL1 LAX1 NUP62 PEX5 PRDM14 SUMO4 TMOD4 UBL7 ZHX1
Entrez ID		11244	3417
HPRD ID		10379	00984
Ensembl ID		ENSG00000165156	ENSG00000138413
Uniprot IDs		A0A024R9F1 Q9UKY1	A0A024R3Y6 O75874
PDB IDs		2ECB 2GHF 2LY9 3NAR	1T09 1T0L 3INM 3MAP 3MAR 3MAS 4I3K 4I3L 4KZO 4L03 4L04 4L06 4UMX 4UMY 4XRX 4XS3 5DE1 5GIR 5K10 5K11 5L57 5L58 5LGE 5SUN 5SVF 5TQH 5YFM 5YFN 6ADG 6B0Z 6BKX 6BKY 6BKZ 6BL0 6BL1 6BL2 6IO0 6O2Y 6O2Z 6PAY 6Q6F
Enriched GO Terms of Interacting Partners?
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