PRDM4 and MSRB3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PRDM4	MSRB3
Description		PR/SET domain 4	methionine sulfoxide reductase B3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Histone Methyltransferase Complex	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding Histone Methyltransferase Binding	Protein Binding Zinc Ion Binding Peptide-methionine (R)-S-oxide Reductase Activity L-methionine-(R)-S-oxide Reductase Activity
	Biological Process	Transcription By RNA Polymerase II Histone H4-R3 Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Response To Oxidative Stress Protein Repair Oxidation-reduction Process
Pathways		p75NTR negatively regulates cell cycle via SC1	Protein repair
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Sleep duration ( 30846698)	Antisaccade task score ( 31596458) Birth weight ( 31043758) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) Differentiated thyroid cancer ( 28703219) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Height ( 31562340) Hippocampal fissure volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal volume ( 28098162 22504421) Lung function (FEV1) ( 28166213) Lung function (FVC) ( 30804560) Papillary thyroid cancer ( 28703219) Peak expiratory flow ( 30804560) Post bronchodilator FEV1/FVC ratio ( 26634245) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Subcortical brain region volumes ( 25607358) Subiculum volume ( 30279459) Temperament ( 22832960) Temporal lobe volume ( 31396565) Total hippocampal volume ( 30279459) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		6 interacting genes: CTNNBL1 EIF4E EMX1 MSRB3 SERTAD1 SMAD3	6 interacting genes: GOLGA2 LNX2 MAPK8IP2 PRDM4 TCF4 TRIP6
Entrez ID		11108	253827
HPRD ID		10425	14785
Ensembl ID		ENSG00000110851	ENSG00000174099
Uniprot IDs		A0A024RBM7 B3KPI0 Q9UKN5	Q8IXL7
PDB IDs		2L9Z 3DB5
Enriched GO Terms of Interacting Partners?
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