PRDM4 and EIF4E

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		PRDM4	EIF4E
Description		PR/SET domain 4	eukaryotic translation initiation factor 4E
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Histone Methyltransferase Complex	P-body Cytoplasm Cytosol MRNA Cap Binding Complex Cytoplasmic Stress Granule Eukaryotic Translation Initiation Factor 4F Complex RISC Complex Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding Histone Methyltransferase Binding	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Enzyme Binding Eukaryotic Initiation Factor 4G Binding Repressing Transcription Factor Binding
	Biological Process	Transcription By RNA Polymerase II Histone H4-R3 Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	G1/S Transition Of Mitotic Cell Cycle Behavioral Fear Response RNA Export From Nucleus MRNA Export From Nucleus Translational Initiation Regulation Of Translation Negative Regulation Of Autophagy Viral Process Negative Regulation Of Translation Stem Cell Population Maintenance Lung Development Negative Regulation Of Neuron Differentiation Positive Regulation Of Mitotic Cell Cycle Cellular Response To Dexamethasone Stimulus Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission
Pathways		p75NTR negatively regulates cell cycle via SC1	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript mTORC1-mediated signalling Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs			7-Methyl-Gpppa 7n-Methyl-8-Hydroguanosine-5'-Diphosphate 7-Methyl-Guanosine-5'-Triphosphate LY2275796 S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate
Diseases
GWAS		Acne (severe) ( 24927181) Sleep duration ( 30846698)	Alcohol consumption (drinks per week) ( 30643258 30679032) Daytime sleep phenotypes ( 27126917) Menopause (age at onset) ( 29773799) Sensation seeking ( 30718321)
Interacting Genes		6 interacting genes: CTNNBL1 EIF4E EMX1 MSRB3 SERTAD1 SMAD3	25 interacting genes: APP BIRC2 CD83 EIF4B EIF4EBP1 EIF4EBP2 EIF4EBP3 EIF4ENIF1 EIF4G1 EIF4G2 EIF4G3 EMX2 GEMIN5 KANK2 MAPKAPK5 MKNK1 MKNK2 PML PRDM4 PRKCA PRKCB PRKCG TDO2 TRIM27 UBXN11
Entrez ID		11108	1977
HPRD ID		10425	00591
Ensembl ID		ENSG00000110851	ENSG00000151247
Uniprot IDs		A0A024RBM7 B3KPI0 Q9UKN5	D6RBW1 P06730 Q32Q75 X5D7E3
PDB IDs		2L9Z 3DB5	1IPB 1IPC 1WKW 2GPQ 2V8W 2V8X 2V8Y 2W97 3AM7 3TF2 3U7X 4AZA 4BEA 4DT6 4DUM 4TPW 4TQB 4TQC 4UED 5EHC 5EI3 5EIR 5EKV 5GW6 5T46 5ZJY 5ZJZ 5ZK5 5ZK7 5ZK9 5ZML
Enriched GO Terms of Interacting Partners?
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