NUP50 and KPNA3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		NUP50	KPNA3
Description		nucleoporin 50	karyopherin subunit alpha 3
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Pore Nucleoplasm Nuclear Membrane Intracellular Membrane-bounded Organelle Host Cell	Nuclear Pore Nucleoplasm Cytosol Host Cell
	Molecular Function	Protein Binding	Protein Binding Protein C-terminus Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Regulation Of Glycolytic Process MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Viral Process Protein Sumoylation Viral Transcription Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat	NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Process Viral Entry Into Host Cell Protein-containing Complex Assembly Viral Penetration Into Host Nucleus
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS			Inflammatory skin disease ( 25574825) Menopause (age at onset) ( 22267201) Obesity-related traits ( 23251661) Triiodothyronine/thyroxine ratio ( 30824882)
Interacting Genes		10 interacting genes: APP CDKN1B IPO13 KPNA2 KPNA3 KPNA6 KPNB1 RAN SRPK2 XPO1	33 interacting genes: APOL6 ARNT CDKN1B COIL DDX21 EPAS1 EPHA2 ERCC3 FAM50B FTL GATA6 GTF2H1 GTF2IRD1 HIF1A HNRNPC HSPB1 KPNB1 MAT2B MVP MYOD1 NFE2L2 NFKB1 NUP50 RBBP4 RCC1 RPRD1A SLC5A11 TEX37 TGM2 TSSC4 ZBTB24 ZCCHC10 ZNF131
Entrez ID		10762	3839
HPRD ID		05226	03536
Ensembl ID		ENSG00000093000	ENSG00000102753
Uniprot IDs		A0A024R4X7 B4E2D3 Q9UKX7	A0A024RDV7 O00505
PDB IDs		2EC1 3TJ3
Enriched GO Terms of Interacting Partners?
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