SORBS1 and SH2B2

Number of citations of the paper that reports this interaction (PubMedID 11997497)
52

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		SORBS1	SH2B2
Description		sorbin and SH3 domain containing 1	SH2B adaptor protein 2
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GO Annotations	Cellular Component	Stress Fiber Nucleus Centrosome Cytosol Insulin Receptor Complex Adherens Junction Zonula Adherens Focal Adhesion Nuclear Matrix Cell-substrate Junction Membrane Raft	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Actin Binding SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Muscle Contraction Cell-matrix Adhesion Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Protein Localization To Plasma Membrane	Signal Transduction Blood Coagulation Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway
Pathways		Smooth Muscle Contraction	Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Diabetic nephropathy in type 1 diabetes ( 25476525) Estimated glomerular filtration rate ( 31152163) Obesity-related traits ( 23251661) PR interval ( 30046033) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Suicide risk ( 21041247)	Type 2 diabetes ( 31049640)
Interacting Genes		25 interacting genes: ABL1 ACTA1 ADAM15 AFDN CBL CDK6 EFNB1 FLOT1 INPPL1 INSM1 INSR KHDRBS1 MAP4K3 PAK2 PGR PILRA PTK2 PXN RPL4 SEMA6A SH2B2 SLC10A3 SRC TENM1 VCL	22 interacting genes: AKT1 ASB6 BTK CBL EPOR ERBB2 FYN GRB2 INSR JAK1 JAK2 JAK3 KIT LYN MTDH NTRK1 NTRK2 PDLIM7 SH2B1 SHC1 SORBS1 SYK
Entrez ID		10580	10603
HPRD ID		05587	16097
Ensembl ID		ENSG00000095637	ENSG00000160999
Uniprot IDs		B4DTX5 Q9BX66	O14492
PDB IDs		2DL3 2ECZ 2LJ0 2LJ1 2MOX 2O2W 2O31 2O9S 2O9V 4LN2 4LNP	1Q2H
Enriched GO Terms of Interacting Partners?
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